An obesity genetic risk score is associated with metabolic syndrome in Chinese children.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland, 1976-
    • Subject Terms:
      Asian People/*genetics ; Metabolic Syndrome/*complications ; Metabolic Syndrome/*genetics ; Obesity/*complications ; Obesity/*genetics; Adolescent ; Alleles ; Child ; China ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors
    • Abstract:
      Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/obesity. In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (MetS) in a children population from China. A total of 431 children with MetS and 3046 controls were identified based on the modified ATPIII definition. 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265, FAIM2 rs7138803, NPC1 rs1805081, SEC16B rs10913469, SH2B1 rs4788102, PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479) were genotyped by TaqMan 7900. Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, P=0.016; BDNF rs6265: OR=1.19, 95% CI=1.03-1.39, P=0.021; FAIM2 rs7138803: OR=1.20, 95% CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95% CI=1.04-1.15, P=5.26×10(-4)). After further adjustment for BMI, none of SNPs were associated with risk of MetS (all P>0.05); the association between GRS and risk of MetS remained nominally (OR=1.02, 95%CI=0.96-1.08, P=0.557). However, after correction for multiple testing, only GRS was statistically associated with risk of MetS in the model without adjustment for BMI. The present study demonstrated that there were nominal associations of GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 with risk of MetS. The SNPs in combination have a significant effect on risk of MetS among Chinese children. These associations above were mediated by adiposity.
      (Copyright © 2013 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: BCAMS; BMI; CI; Children; Chinese; DBP; FG; FTO; GRS; GWAS; HDL-C; HDL-cholesterol; HWE; Hardy–Weinberg equilibrium; LDL-C; LDL-cholesterol; MetS; Metabolic syndrome; OR; Obesity; Polymorphism; SBP; SNP; TC; TG; body mass index; confidence interval; diastolic blood pressure; fasting glucose; fat mass- and obesity associated; genetic risk score; genome-wide association study; metabolic syndrome; odds ratio; single nucleotide polymorphism; systolic blood pressure; the Beijing Child and Adolescent Metabolic Syndrome; total cholesterol; triglyceride
    • Publication Date:
      Date Created: 20131126 Date Completed: 20140311 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.gene.2013.11.006
    • Accession Number:
      24269186