Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier, c1993-
    • Subject Terms:
      Anti-Bacterial Agents/*pharmacology ; Cyclodextrins/*pharmacology ; Escherichia coli/*drug effects ; Nanofibers/*chemistry ; Staphylococcus aureus/*drug effects ; Triclosan/*pharmacology; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Cyclodextrins/chemistry ; Electric Conductivity ; Electrodes ; Microbial Sensitivity Tests ; Molecular Structure ; Particle Size ; Surface Properties ; Triclosan/chemistry ; Viscosity
    • Abstract:
      The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were electrospun from highly concentrated (160% CD, w/w) aqueous triclosan/CD-IC suspension by using two types of chemically modified CD; hydroxypropyl-beta-cyclodextrin (HPβCD) and hydroxypropyl-gamma-cyclodextrin (HPγCD). The morphological characterization of the electrospun triclosan/CD-IC NF by SEM elucidated that the triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF were bead-free having average fiber diameter of 520 ± 250 nm and 1,100 ± 660 nm, respectively. The presence of triclosan and the formation of triclosan/CD-IC within the fiber structure were confirmed by (1)H-NMR, FTIR, XRD, DSC, and TGA studies. The initial 1:1 molar ratio of the triclosan:CD was kept for triclosan/HPβCD-IC NF after the electrospinning and whereas 0.7:1 molar ratio was observed for triclosan/HPγCD-IC NF and some uncomplexed triclosan was detected suggesting that the complexation efficiency of triclosan with HPγCD was lower than that of HPβCD. The antibacterial properties of triclosan/CD-IC NF were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. It was observed that triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF showed better antibacterial activity against both bacteria compared to uncomplexed pure triclosan.
      (Copyright © 2013 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antibacterial activity; Cyclodextrin; Electrospinning; Inclusion complex; Nanofibers; Triclosan
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Cyclodextrins)
      4NM5039Y5X (Triclosan)
    • Publication Date:
      Date Created: 20131123 Date Completed: 20141209 Latest Revision: 20140421
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.colsurfb.2013.10.029
    • Accession Number:
      24262865