Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.

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  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Cholinesterase Reactivators/*pharmacology ; Organophosphate Poisoning/*drug therapy ; Oximes/*pharmacology; Antidotes/therapeutic use ; Cholinesterase Reactivators/chemistry ; Cholinesterase Reactivators/therapeutic use ; Female ; Humans ; Oximes/chemistry ; Oximes/therapeutic use ; Pralidoxime Compounds/therapeutic use ; Pregnancy
    • Abstract:
      Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs irreversibly inhibit acetylcholinesterase (AChE) at nerve synapses. Furthermore, the role of AChE other than neurotransmission termination has been defined in the literature. The growing evidences show that cholinergic mechanisms are involved during growth and development of other organ systems. In contrary to the fact, the data on the use of oxime-AChER in OPC poisoning in pregnancy are scanty. The present review aimed to comprehend the status of oximes in pregnancy in lieu of the published literature. A thorough literature search was performed in January 2013, using ten popular search engines including Medline/PubMed, Google scholar, etc., using nine standard keywords. The search period was set from 1966 to present. The search did not reveal substantial data. No considerable studies were retrieved which could really demonstrate either the beneficial, harmful or even null effect of oxime-AChER usage in pregnancy. Only eighteen relevant articles were obtained for a period of about 47 years. In the literature, there is no report available to demonstrate the risk of using oxime-AChER in pregnancy for the treatment of OPC poisoning. The study reveals that the use of oxime-AChER in pregnancy is largely un-addressed, inconclusive and based on speculation albeit the incidences of OPC poisoning are quite prevalent. Well-designed studies are warranted for a tangible conclusion.
    • Accession Number:
      0 (Antidotes)
      0 (Cholinesterase Reactivators)
      0 (Oximes)
      0 (Pralidoxime Compounds)
      P7MU9UTP52 (pralidoxime)
    • Publication Date:
      Date Created: 20131122 Date Completed: 20150512 Latest Revision: 20140218
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00204-013-1160-z
    • Accession Number:
      24258240