Biomarkers of arsenic exposure and effects in a Canadian rural population exposed through groundwater consumption.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Nature Pub. Group, c2006-
    • Subject Terms:
      Environmental Exposure* ; Rural Population*; Arsenic/*toxicity ; Biomarkers/*analysis; 8-Hydroxy-2'-Deoxyguanosine ; Adolescent ; Adult ; Aged ; Arsenic/analysis ; Canada ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/urine ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity ; Young Adult
    • Abstract:
      Drinking water intake of arsenic (As) from private wells may represent a significant exposure pathway and induce oxidative DNA damage. We measured total As concentrations in hair and nails, and concentrations of the different species of As and its metabolites as well as 8-OHdG in urine of 110 non-smoking adults living in a rural region of the Province of Quebec, Canada. Significant differences in exposure biomarker levels were observed between individuals consuming drinking water with As levels of≤1.0,>1.0 -≤10 and>10 μg/l. Multivariate linear regression analysis also showed a significant relationship between estimated daily drinking water intakes of As and biomarker levels. Conversely, 8-OHdG levels were not significantly related to daily drinking water intakes of As or to hair, nail or urinary exposure biomarker levels, according to multivariate linear regression analysis. Even at the relatively low levels of As found in well water of our participants, water consumption significantly increases their body load of As, as confirmed by multiple matrix measurements, which reflected exposure over different time frames. However, this increased internal As dose was not associated with higher oxidative damage to DNA as reflected by urinary 8-OHdG levels.
    • References:
      Epidemiology. 2000 Nov;11(6):673-9. (PMID: 11055628)
      Toxicol Appl Pharmacol. 2001 Aug 1;174(3):282-93. (PMID: 11485389)
      Clin Toxicol (Phila). 2007 Jun-Aug;45(5):490-8. (PMID: 17503254)
      Am J Epidemiol. 1990 Jul;132(1):114-22. (PMID: 2356804)
      J Expo Sci Environ Epidemiol. 2009 Jan;19(1):59-68. (PMID: 18523458)
      Environ Health Perspect. 2005 Feb;113(2):192-200. (PMID: 15687057)
      Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):101-10. (PMID: 20056628)
      J Sports Sci. 1996 Aug;14(4):343-6. (PMID: 8887214)
      Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2419-26. (PMID: 16214926)
      Lancet. 1994 Sep 24;344(8926):862-3. (PMID: 7916406)
      J Expo Sci Environ Epidemiol. 2008 Mar;18(2):149-57. (PMID: 17426735)
      Am J Epidemiol. 2000 Jul 1;152(1):84-90. (PMID: 10901333)
      Clin Chim Acta. 2004 Jan;339(1-2):1-9. (PMID: 14687888)
      Zentralbl Hyg Umweltmed. 1996 Jul;198(6):485-501. (PMID: 9353539)
      Environ Res. 2006 Jun;101(2):213-20. (PMID: 16188251)
      Epidemiology. 2010 Jan;21(1):103-8. (PMID: 20010213)
      Med Lav. 2012 Sep-Oct;103(5):372-81. (PMID: 23077797)
      Environ Res. 2004 Oct;96(2):119-26. (PMID: 15325872)
      Toxicol Appl Pharmacol. 2004 Aug 1;198(3):291-6. (PMID: 15276408)
      Food Addit Contam. 2007 May;24(5):447-534. (PMID: 17487664)
      J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):182-90. (PMID: 21878987)
      J Environ Monit. 2009 Mar;11(3):610-7. (PMID: 19280039)
      Dermatol Clin. 1985 Jul;3(3):373-81. (PMID: 3830499)
      Environ Health Perspect. 2003 Feb;111(2):187-93. (PMID: 12573904)
      Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61. (PMID: 11312654)
      Am J Clin Nutr. 1993 Mar;57(3):408-13. (PMID: 8438776)
      J Expo Anal Environ Epidemiol. 2005 Mar;15(2):147-52. (PMID: 15150536)
      Cancer Epidemiol Biomarkers Prev. 1996 Oct;5(10):849-52. (PMID: 8896897)
      Am J Epidemiol. 2001 Mar 15;153(6):559-65. (PMID: 11257063)
      J Toxicol Environ Health B Crit Rev. 2009 Aug;12(7):509-24. (PMID: 20183531)
      J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39. (PMID: 19412858)
      Forensic Sci Int. 1993 Dec;63(1-3):9-18. (PMID: 8138238)
      Environ Health Perspect. 2001 Dec;109(12):1265-70. (PMID: 11748034)
      J Toxicol Environ Health A. 2007 Jan 15;70(2):148-58. (PMID: 17365576)
      Br J Cancer. 1986 Mar;53(3):399-405. (PMID: 3964542)
      Environ Health Perspect. 2000 Nov;108(11):1015-8. (PMID: 11102289)
      IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477. (PMID: 15645578)
      Toxicol Lett. 2003 Jan 31;137(1-2):3-13. (PMID: 12505428)
      J AOAC Int. 1993 Jan-Feb;76(1):14-25. (PMID: 8448438)
      IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440. (PMID: 3482203)
    • Accession Number:
      0 (Biomarkers)
      0 (Water Pollutants, Chemical)
      88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
      G9481N71RO (Deoxyguanosine)
      N712M78A8G (Arsenic)
    • Publication Date:
      Date Created: 20131107 Date Completed: 20141014 Latest Revision: 20211021
    • Publication Date:
      20221213
    • Accession Number:
      10.1038/jes.2013.80
    • Accession Number:
      24192660