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Wando Mount Pleasant Library
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Otranto Road Library
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Effect of Bauhinia racemosa Stem Bark on N-nitrosodiethylamine-Induced Hepatocarcinogenesis in Rats.
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- Author(s): Kumar, Ramanathan Sambath; Sunderam, Rajagopal Shanmuga; Sivakumar, Thangavel; Sivakumar, Palanivel; Sureshkumar, Raman; Kanagasabi, Rengaswamy; Vijaya, Manickum; Perumal, Baskaran Perumal; Gupta, Malaya; Mazumdar, Upal; Kumar, Mani Senthil; Kumar, Kuppuswamy Asok
- Source:
American Journal of Chinese Medicine; 2007, Vol. 35 Issue 1, p103-114, 12p, 1 Chart, 6 Graphs- Subject Terms:
- Source:
- Additional Information
- Abstract: The aim of this study is to investigate the antioxidant defense system induced by the methanol extract of Bauhinia racemosa L.(MEBR) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in Wister albino rats. The effects of MEBR on surface visible macroscopic (Morphometry) liver lesions (neoplastic nodules) and the levels of serum enzymes, lipid peroxidation and antioxidants were evaluated in NDEA-induced hepatocarcinogenesis in rats.In rats treated, with NDEA, significantly elevated levels of serum enzymes (SGOT, SGPT and ALP), bilirubin and decreased levels of protein and uric acid were observed. Significantly elevated amount of malondialdehyde (MDA), the end product of lipidperoxidation, indicated higher levels of lipid peroxidation, which was accompanied by significantly decreased levels of antioxidants like vitamin C, vitamin E, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Administration of MEBR was able to suppress nodule development/hepatocellular lesion formation in rats. The extract treatment increases in antioxidant levels and dramatic decreases in lipid peroxidation levels. MEBR also produced a protective effect by decreasing the level of serum enzymes, bilirubin and increased the protein and uric acid levels. The results suggest that MEBR exert chemopreventive effects by suppressing nodule development and decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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