[Lithium nephropathy].

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  • Author(s): Kaczmarczyk I;Kaczmarczyk I; Sułowicz W
  • Source:
    Przeglad lekarski [Przegl Lek] 2013; Vol. 70 (6), pp. 397-9.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Polish
  • Additional Information
    • Transliterated Title:
      Nefropatia litowa.
    • Source:
      Publisher: Wydawnicto Przeglad Lekarski Country of Publication: Poland NLM ID: 19840720R Publication Model: Print Cited Medium: Print ISSN: 0033-2240 (Print) Linking ISSN: 00332240 NLM ISO Abbreviation: Przegl Lek Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kraków : Wydawnicto Przeglad Lekarski
    • Subject Terms:
      Kidney Diseases/*chemically induced ; Kidney Diseases/*prevention & control ; Lithium Compounds/*adverse effects; Biopsy ; Humans ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Renal Replacement Therapy
    • Abstract:
      Lithium salts are the first-line drug therapy in the treatment of uni- and bipolar disorder since the sixties of the twentieth century. In the mid-70s, the first information about their nephrotoxicity appeared. Lithium salts have a narrow therapeutic index. Side effects during treatment are polyuria, polydipsia and nephrogenic diabetes insipidus. Accidental intoxication can cause acute renal failure requiring renal replacement therapy while receiving long-term lithium salt can lead to the development of chronic kidney disease. The renal biopsy changes revealed a type of chronic tubulointerstitial nephropathy. The imaging studies revealed the presence of numerous symmetric microcysts. Care of the patient receiving lithium should include regular determination of serum creatinine, creatinine clearance and monitoring of urine volume. In case of deterioration of renal function reducing the dose should be considered.
    • Accession Number:
      0 (Lithium Compounds)
    • Publication Date:
      Date Created: 20130924 Date Completed: 20131119 Latest Revision: 20130923
    • Publication Date:
      20221213
    • Accession Number:
      24052977