Functional and molecular imaging techniques in aortic aneurysm disease.

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  • Author(s): Hope MD;Hope MD; Hope TA
  • Source:
    Current opinion in cardiology [Curr Opin Cardiol] 2013 Nov; Vol. 28 (6), pp. 609-18.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Williams and Wilkins Country of Publication: United States NLM ID: 8608087 Publication Model: Print Cited Medium: Internet ISSN: 1531-7080 (Electronic) Linking ISSN: 02684705 NLM ISO Abbreviation: Curr Opin Cardiol Subsets: MEDLINE
    • Publication Information:
      Publication: Philadelphia Pa : Lippincott Williams and Wilkins
      Original Publication: London ; New York : Gower Academic Journals, c1986-
    • Subject Terms:
      Aorta*/diagnostic imaging ; Aorta*/metabolism ; Aorta*/pathology; Aortic Aneurysm/*diagnosis ; Magnetic Resonance Imaging/*methods ; Molecular Imaging/*methods ; Positron-Emission Tomography/*methods; Aortic Aneurysm/diagnostic imaging ; Collagen/metabolism ; Elastin/metabolism ; Fluorodeoxyglucose F18 ; Humans ; Radiopharmaceuticals
    • Abstract:
      Purpose of Review: Functional and molecular aortic imaging has shown great promise for evaluation of aortic disease, and may soon augment conventional assessment of aortic dimensions for the clinical management of patients.
      Recent Findings: A range of imaging techniques is available for evaluation of patients with aortic disease. Magnetic resonance blood flow imaging can identify atherosclerosis prone aortic regions and may be useful for predicting aneurysm growth. Computational modeling can demonstrate significant differences in wall stress between abdominal aortic aneurysms of similar size and may better predict rupture than diameter alone. Metabolic imaging with fluorodeoxyglucose-PET [(FDG)-PET] can identify focal aortic wall inflammation that may portend rapid progression of disease. Molecular imaging with probes that target collagen and elastin can directly exhibit changes in the vessel wall associated with disease.
      Summary: The complexity of aortic disease is more fully revealed with new functional imaging techniques than with conventional anatomic analysis alone. This may better inform surveillance imaging regimens, medical management and decisions regarding early intervention for aortic disease.
    • Accession Number:
      0 (Radiopharmaceuticals)
      0Z5B2CJX4D (Fluorodeoxyglucose F18)
      9007-34-5 (Collagen)
      9007-58-3 (Elastin)
    • Publication Date:
      Date Created: 20130914 Date Completed: 20140522 Latest Revision: 20161125
    • Publication Date:
      20221213
    • Accession Number:
      10.1097/HCO.0b013e3283644beb
    • Accession Number:
      24030165