[Alcohol dehydrogenase - physiological and diagnostic Importance].

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  • Author(s): Łaniewska-Dunaj M;Łaniewska-Dunaj M; Jelski W; Szmitkowski M
  • Source:
    Postepy higieny i medycyny doswiadczalnej (Online) [Postepy Hig Med Dosw (Online)] 2013 Aug 27; Vol. 67, pp. 901-7. Date of Electronic Publication: 2013 Aug 27.
  • Publication Type:
    Journal Article; Review
  • Language:
    Polish
  • Additional Information
    • Transliterated Title:
      Dehydrogenaza alkoholowa - znaczenie fizjologiczne i diagnostyczne.
    • Source:
      Publisher: Medical Science International Country of Publication: Poland NLM ID: 101206517 Publication Model: Electronic Cited Medium: Internet ISSN: 1732-2693 (Electronic) Linking ISSN: 00325449 NLM ISO Abbreviation: Postepy Hig Med Dosw (Online) Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Warsaw, Poland] : Medical Science International, [2004]-
    • Subject Terms:
      Alcohol Dehydrogenase/*metabolism ; Biomarkers, Tumor/*blood ; Digestive System Neoplasms/*diagnosis ; Digestive System Neoplasms/*enzymology ; Liver Diseases/*diagnosis ; Liver Diseases/*enzymology; Aldehyde Dehydrogenase/metabolism ; Humans ; Isoenzymes/metabolism ; Liver Neoplasms/diagnosis ; Liver Neoplasms/enzymology
    • Abstract:
      Alcohol dehydrogenase (ADH) is a polymorphic enzyme, existing in multiple isoenzymes divided into several classes and localized in different organs. ADH plays a significant role in the metabolism of many biologically important substances, catalyzing the oxidation or reduction of a wide spectrum of specific substrates. The best characterized function of ADH is protection against excess of ethanol and some other exogenous xenobiotics and products of lipid peroxidation. The isoenzymes of alcohol dehydrogenase also participate in the metabolism of retinol and serotonin. The total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy organs (e.g. liver, stomach, colorectum). The changes in activity of particular ADH isoenzymes in the sera of patients with different cancers (especially of the digestive system) seem to be caused by release of these isoenzymes from cancer cells, and may play a potential role as markers of this cancer. The particular isoenzymes of ADH present in the serum may indicate the cancer localization. Alcohol dehydrogenase may also be useful for diagnostics of non-cancerous liver diseases (e.g. viral hepatitis, non-alcoholic cirrhosis).
    • Accession Number:
      0 (Biomarkers, Tumor)
      0 (Isoenzymes)
      EC 1.1.1.1 (Alcohol Dehydrogenase)
      EC 1.2.1.3 (Aldehyde Dehydrogenase)
    • Publication Date:
      Date Created: 20130911 Date Completed: 20140429 Latest Revision: 20191112
    • Publication Date:
      20240829
    • Accession Number:
      10.5604/17322693.1064330
    • Accession Number:
      24018456