Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE

Publication: [London] : Taylor & Francis
Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998-

Antineoplastic Agents, Phytogenic/*pharmacology ; Drugs, Chinese Herbal/*pharmacology ; Lignans/*pharmacology ; Neoplasms/*drug therapy ; Plant Stems/*chemistry ; Schisandra/*chemistry ; Triterpenes/*pharmacology; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm ; Drugs, Chinese Herbal/chemistry ; Ether/chemistry ; Ethnopharmacology ; Humans ; Inhibitory Concentration 50 ; Lignans/chemistry ; Lignans/isolation & purification ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Solvents/chemistry ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Tubulin Modulators/therapeutic use ; Vincristine/therapeutic use

Context: The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited.
Objective: Elucidation of the cytotoxic constituents of S. pubescens was performed.
Methods: Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.
Results: Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM.
Conclusion: The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.

CA-17625 United States CA NCI NIH HHS

0 (Antineoplastic Agents, Phytogenic)
0 (Drugs, Chinese Herbal)
0 (Lignans)
0 (Plant Extracts)
0 (Solvents)
0 (Triterpenes)
0 (Tubulin Modulators)
0F5N573A2Y (Ether)
5J49Q6B70F (Vincristine)

Date Created: 20130726 Date Completed: 20140310 Latest Revision: 20151119

20221213

10.3109/13880209.2013.818039

23883077