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Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant.
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- Author(s): Dewanjee S;Dewanjee S; Dua TK; Sahu R
- Source:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Sep; Vol. 59, pp. 514-20. Date of Electronic Publication: 2013 Jul 02.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE
- Publication Information:
Publication: Exeter : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, c1982-
- Subject Terms:
- Abstract:
Leea macrophylla (Leeaceae) is a wild edible plant with ethomedicinal importance as anti-inflammatory agent. However, no systematic studies on its anti-inflammatory activity and mechanisms have been reported. Present study was undertaken to evaluate anti-inflammatory activity of methanol extract of L. macrophylla leaves. Phytochemical investigation revealed presence of sterols, triterpenoids and ascorbic acid in extract. Methanol extract inhibited lipopolysaccharide stimulated production of inflammatory mediators viz. prostaglandin E2, tumor necrotic factor-α, interleukin-6 and interleukin-1β in vitro in mouse peritoneal macrophages. Additionally, the in vivo anti-inflammatory activity of this extract was evaluated by using carrageenan induced paw edema and cotton pellet granuloma assays in experimental rats. Oral administration of extract (100 and 200 mg/kg) exhibited dose dependant inhibition of carrageenan induced inflammation (p<0.05) and the reduction of the granuloma tissue formation (p<0.05-0.01). The extract (100 and 200 mg/kg, orally) exhibited significant central and peripheral analgesic activity in hot-plate test (p<0.01) and acetic acid induced writhing test (p<0.05-0.01) respectively in experimental mice. Treatment with extract (100 and 200 mg/kg, orally) significantly reduced the yeast provoked elevated body temperature (p<0.05-0.01) in experimental rats. These results confirmed the traditional anti-inflammatory indication of L. macrophylla leaves.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Contributed Indexing:
Keywords: Analgesic; Anti-inflammatory; Leea macrophylla; Methanol extract
- Accession Number:
0 (Anti-Inflammatory Agents)
0 (Phytosterols)
0 (Plant Extracts)
0 (Triterpenes)
PQ6CK8PD0R (Ascorbic Acid)
- Publication Date:
Date Created: 20130709 Date Completed: 20140328 Latest Revision: 20130819
- Publication Date:
20221213
- Accession Number:
10.1016/j.fct.2013.06.038
- Accession Number:
23831308
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