Vitamin K1 levels and K1-dependent coagulation factors II and X in preterm and small-for-date neonates.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print Cited Medium: Print ISSN: 0340-6199 (Print) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin, New York, Springer-Verlag.

Factor X/*analysis ; Infant, Premature/*blood ; Infant, Small for Gestational Age/*blood ; Prothrombin/*analysis ; Vitamin K 1/*blood; Fetal Blood/analysis ; Humans ; Infant, Newborn ; Vitamin K Deficiency Bleeding/etiology

In 17 preterm neonates and 7 small-for-date neonates, all formula-fed, vitamin K-dependent coagulation factors II and X remained near 45% of adult values from the moment of birth until 28 days postnatally. Vitamin K1 levels, however, showed a remarkable rise from below the detection limit of 0.022 ng/ml in umbilical cord blood, to serum levels with a range of 0.99-7.29 ng/ml vitamin K1 on day 3, with a further rise on days 7 and 28 postnatally. Vitamin K1 (Konakion) parenterally given to a third group of four preterm neonates as a 1 mg dose resulted in very high serum levels of vitamin K1 (64.08-157.10 ng/ml), but without any significant increase in plasma levels of vitamin K-dependent coagulation factors II and X, compared to the group without any extra vitamin K1. It is concluded that in healthy preterm and small-for-date neonates no correlation is seen between serum levels of vitamin K1 and plasma levels of coagulation factors II and X. After administration of 1 mg Konakion no accelerated increase is seen in coagulation factor activities.

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84-80-0 (Vitamin K 1)
9001-26-7 (Prothrombin)
9001-29-0 (Factor X)

Date Created: 19900601 Date Completed: 19900828 Latest Revision: 20190813

20231215

10.1007/BF02034753

2373117