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Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.
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- Author(s): Liu YF;Liu YF; Swart M; Ke Y; Ly K; McDonald FJ
- Source:
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2013 Jul 01; Vol. 305 (1), pp. F80-9. Date of Electronic Publication: 2013 May 01.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE
- Publication Information:
Original Publication: Bethesda, Md. : American Physiological Society, c1997-
- Subject Terms:
- Abstract:
The epithelial sodium channel (ENaC) plays an important role in controlling Na⁺ homeostasis, extracellular fluid volume, and blood pressure. Copper metabolism Murr1 domain-containing protein 1 (COMMD1) interacts with ENaC and downregulates ENaC. COMMD1 belongs to the COMMD family consisting of COMMD1-10, and all COMMD family members share a C-terminal COMM domain. Here, we report that COMMD2-10 also interacts with ENaC, and COMMD3 and COMMD9 were selected for further study. Amiloride-sensitive current in mammalian epithelia expressing ENaC was significantly reduced by COMMD3 or COMMD9, and ENaC expression at the cell surface was significantly decreased in the presence of COMMD3 or COMMD9. COMMD3 and COMMD9 retained their ability to reduce current when COMMD1 was knocked down. COMMD3 and COMMD9 were widely expressed in kidney and were colocalized with ENaC in renal collecting duct cells. These data suggest that COMMD3 and COMMD9 may be endogenous regulators of ENaC to regulate Na⁺ transport through altering ENaC cell surface expression.
- Contributed Indexing:
Keywords: ENaC; amiloride; kidney
- Accession Number:
0 (Adaptor Proteins, Signal Transducing)
0 (COMMD3 protein, rat)
0 (COMMD9 protein, rat)
0 (Epithelial Sodium Channel Blockers)
0 (Epithelial Sodium Channels)
0 (Protein Subunits)
7DZO8EB0Z3 (Amiloride)
9NEZ333N27 (Sodium)
- Publication Date:
Date Created: 20130503 Date Completed: 20130906 Latest Revision: 20191210
- Publication Date:
20221213
- Accession Number:
10.1152/ajprenal.00158.2013
- Accession Number:
23637203
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