Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE
    • Publication Information:
      Publication: 2017- : New York : Oxford University Press
      Original Publication: New York, Raven Press.
    • Subject Terms:
      Ethnicity* ; White People*; C-Reactive Protein/*metabolism ; Sleep Wake Disorders/*blood ; Sleep Wake Disorders/*ethnology; Adult ; Aged ; Biomarkers/blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Self Report ; Sex Factors ; United States
    • Abstract:
      Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk.
      Design: Cross-sectional.
      Setting: Population-based research.
      Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults).
      Interventions: None.
      Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/ Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex.
      Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.
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    • Grant Information:
      K23 HL110216 United States HL NHLBI NIH HHS; R21 ES022931 United States ES NIEHS NIH HHS; K23HL110216 United States HL NHLBI NIH HHS; R21ES022931 United States ES NIEHS NIH HHS; T32HL007713 United States HL NHLBI NIH HHS; P01 AG009975 United States AG NIA NIH HHS; UL1RR024134 United States RR NCRR NIH HHS; R01 HL107240 United States HL NHLBI NIH HHS; T32 HL007713 United States HL NHLBI NIH HHS; UL1 RR024134 United States RR NCRR NIH HHS; R01HL107240 United States HL NHLBI NIH HHS; 12SDG9180007 United States PHS HHS
    • Contributed Indexing:
      Keywords: C-reactive protein; cardiovascular disease; epidemiology; inflammation; sleep duration
    • Accession Number:
      0 (Biomarkers)
      9007-41-4 (C-Reactive Protein)
    • Publication Date:
      Date Created: 20130502 Date Completed: 20140109 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      PMC3624831
    • Accession Number:
      10.5665/sleep.2646
    • Accession Number:
      23633760