Clinical and hormonal variables related to bone mass loss in anorexia nervosa patients.

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    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0413601 Publication Model: Print Cited Medium: Internet ISSN: 0083-6729 (Print) Linking ISSN: 00836729 NLM ISO Abbreviation: Vitam Horm Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Anorexia Nervosa/*metabolism ; Bone Density/*physiology ; Osteoporosis/*metabolism; Adolescent ; Female ; Humans ; Young Adult
    • Abstract:
      A better understanding of the prognostic factors of low bone mass in anorexia nervosa (AN) and development of effective therapeutic strategies is critical. In order to determine which clinical, biochemical, and/or hormonal parameters could be related to bone mineral density (BMD), 47 female AN patients were classified according to the WHO osteoporosis criteria at lumbar spine (LS). This was a cross-sectional study of 16 AN women with osteoporosis criteria and 31without. Control group was 25 healthy, normal-weight, age-matched women. We assessed BMD using dual-energy X-ray absorptiometry at the LS and body composition. We measured serum fasting cortisol, estradiol, insulin-like growth factor-1 (IGF-1), leptin, sex hormone-binding globulin, albumin and retinol binding protein levels. The prevalence of osteoporosis was 34% and osteopenia 19% at the LS. The AN group with osteoporosis had lower IGF-1 and estradiol levels (both p<0.001), lower serum leptin (p<0.02), and higher cortisolemia (p<0.03) levels compared with AN group without osteoporosis. The BMD and T-score at LS was inversely related to the duration of amenorrhea (p<0.02) and directly related to body mass index (BMI, p<0.002), total fat mass (p<0.03), serum IGF-1 (p<0.01), and estradiol levels (p<0.001) in AN patients. We conclude that AN women with a significant BMD loss have a high risk of developing osteoporosis. A low BMD is a consequence of hormonal alterations which include hypoestrogenism, hypoleptinemia, hypercortisolism, and decreases in IGF-1 levels, as well as a low BMI and fat mass.
      (Copyright © 2013 Elsevier Inc. All rights reserved.)
    • Publication Date:
      Date Created: 20130423 Date Completed: 20131223 Latest Revision: 20130422
    • Publication Date:
      20240628
    • Accession Number:
      10.1016/B978-0-12-410473-0.00010-6
    • Accession Number:
      23601428