Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.

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  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: United States NLM ID: 8912686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-6887 (Electronic) Linking ISSN: 08982643 NLM ISO Abbreviation: J Aging Health
    • Publication Information:
      Original Publication: [Newbury Park] : Sage Publications, [c1989-
    • Subject Terms:
      Cognition Disorders/*blood ; Folic Acid/*blood ; Vitamin B 12/*blood; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Greece ; Humans ; Male ; Risk Factors ; Socioeconomic Factors
    • Abstract:
      Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece.
      Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived.
      Results: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40).
      Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.
    • Contributed Indexing:
      Keywords: B12; aged; cognitive impairment; folate; meta-analysis
    • Accession Number:
      935E97BOY8 (Folic Acid)
      P6YC3EG204 (Vitamin B 12)
    • Publication Date:
      Date Created: 20130410 Date Completed: 20130823 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10.1177/0898264313482488
    • Accession Number:
      23569157