Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae liver abscess in Taiwan.

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  • Author(s): Lin YT;Lin YT; Liu CJ; Yeh YC; Chen TJ; Fung CP
  • Source:
    The Journal of infectious diseases [J Infect Dis] 2013 Jul 15; Vol. 208 (2), pp. 211-7. Date of Electronic Publication: 2013 Apr 08.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2011- : Oxford : Oxford University Press
      Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
    • Subject Terms:
    • Abstract:
      Background: Klebsiella pneumoniae liver abscess (KPLA) is prevalent in East Asia. Use of amoxicillin/ampicillin may lead to overgrowth of K. pneumoniae in the intestine and predispose to KPLA. We used an animal study and nationwide population-based database to investigate the association between ampicillin/amoxicillin use and KPLA in Taiwan.
      Methods: In an animal study, ampicillin or sterile water was administered orogastrically in serotype K1 K. pneumoniae-colonized mice and the outcome was compared. We identified 855 cases with liver abscess and selected 3420 age- and sex-matched control subjects from the National Health Insurance Research Database. Conditional logistic regression was used to estimate the adjusted odds ratios (ORs) for the association between recent use of ampicillin/amoxicillin and KPLA.
      Results: Ampicillin administration predisposed K. pneumoniae-colonized mice to increased bacterial burden, liver abscess and necrosis, and lethality. The population-based study showed that the adjusted OR associating the use of ampicillin/amoxicillin within the past 30 days with KPLA was 3.5 (95% confidence interval, 2.5-5.1). No association was found with use in the past 31-90 days.
      Conclusions: Ampicillin/amoxicillin therapy started within the past 30 days was associated with increased risk for KPLA. We should avoid the overuse of these antibiotics to prevent undesired disease in the endemic area.
    • Contributed Indexing:
      Keywords: Klebsiella pneumoniae; amoxicillin; ampicillin; liver abscess
    • Accession Number:
      7C782967RD (Ampicillin)
      804826J2HU (Amoxicillin)
    • Publication Date:
      Date Created: 20130410 Date Completed: 20131113 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      10.1093/infdis/jit157
    • Accession Number:
      23568176