Iridoid and bis-iridoid glucosides from the fruit of Gardenia jasminoides.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : [Amsterdam] : Elsevier
      Original Publication: Milano : Inverni & Della Beffa S.p.A.
    • Subject Terms:
      Antiviral Agents/*isolation & purification ; Gardenia/*chemistry ; Iridoid Glucosides/*isolation & purification ; Plant Extracts/*chemistry; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Fruit/chemistry ; Influenza A Virus, H1N1 Subtype/drug effects ; Iridoid Glucosides/chemistry ; Iridoid Glucosides/pharmacology ; Molecular Structure ; Plant Extracts/pharmacology
    • Abstract:
      Three new iridoid glucosides, 6″-O-trans-feruloylgenipin gentiobioside (1), 2'-O-trans-caffeoylgardoside (2), jasmigeniposide A (3), and one new bis-iridoid glucoside, jasmigeniposide B (4), along with six known analogues (5-10), were isolated from the fruit of Gardenia jasminoides. Their structures were established on the basis of spectroscopic analyses and chemical methods. Anti-virus activity of isolated compounds were evaluated in vitro and only compound 9 showed moderate inhibitory activity against H1N1 with 50% effective concentration (EC50) value of 104.36 μM, and selective index (SI) value greater than 4.79.
      (Copyright © 2013 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anti-influenza virus; Bis-iridoid; EV-71; Gardenia jasminoides; H1N1; H3N2; Iridoid glucoside
    • Accession Number:
      0 (Antiviral Agents)
      0 (Iridoid Glucosides)
      0 (Plant Extracts)
    • Publication Date:
      Date Created: 20130410 Date Completed: 20150105 Latest Revision: 20140523
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.fitote.2013.03.025
    • Accession Number:
      23567862