Double-blind, randomized, crossover, controlled clinical trial of NaCl + Chitosan 3% versus NaCl on mild or moderate high blood pressure during the diet and lifestyle improvement period before possible prescription of an antihypertensive treatment.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Allaert FA;Allaert FA
  • Source:
    International angiology : a journal of the International Union of Angiology [Int Angiol] 2013 Feb; Vol. 32 (1), pp. 94-101.
  • Publication Type:
    Comparative Study; Journal Article; Randomized Controlled Trial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Minerva Medica Country of Publication: Italy NLM ID: 8402693 Publication Model: Print Cited Medium: Internet ISSN: 1827-1839 (Electronic) Linking ISSN: 03929590 NLM ISO Abbreviation: Int Angiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Turin, Italy : Minerva Medica, [1982-
    • Subject Terms:
      Diet* ; Double-Blind Method*; Blood Pressure/*drug effects ; Chitosan/*therapeutic use ; Hypertension/*drug therapy ; Sodium Chloride/*therapeutic use; Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Chitosan/pharmacology ; Cross-Over Studies ; Drug Prescriptions ; Female ; Humans ; Life Style ; Male ; Middle Aged ; Severity of Illness Index ; Sodium Chloride/pharmacology
    • Abstract:
      Aim: The aim of the study was to examine the effect on blood pressure of replacing NaCl sea salt by NaCl + chitosan 3% (Symbiosal) during the diet and lifestyle improvement period prescribed to patients before any antihypertensive treatment.
      Methods: This was a double-blind, randomized, crossover, controlled clinical trial of Symbiosal (NaCl + chitosan 3%) versus NaCl over two eight-week periods on 40 patients with mild hypertension for which they had never previously been treated.
      Results: The effect of Symbiosal appeared as early as the first period of the crossover trial showing a reduction in systolic blood pressure (SBP) from 149.2 ± 4.9 mmHg to 136.1 ± 9.5 mmHg in patients on Symbiosal (reduction of 13.1 ± 10.8 mmHg) versus a reduction from 149.7 ± 4.6 mmHg to 142.9 ± 7.7 mmHg in patients on traditional NaCl (reduction of 6.8 ± 7.5 mmHg) (P=0.0404). Similar results were observed for diastolic blood pressure (DBP) with a reduction of 11.2 ± 7.4 mmHg versus 7 ± 8 mmHg (P=0.0560). HBP was brought under control (SBP ≤ 140 and DBP ≤ 90) in 76.2% (16/21) versus 36.8% (7/19)% of patients, respectively (P=0.0119). The crossover analysis confirmed the results showing Symbosial effects for both SBP (P=0.0156) and DBP (P=0.0285).
      Conclusion: Replacing traditional NaCl by Symbiosal in conjunction with recommended alterations to lifestyle and diet significantly contributes to better control of hypertension and may postpone the prescription of antihypertensive drugs.
    • Accession Number:
      0 (Antihypertensive Agents)
      451W47IQ8X (Sodium Chloride)
      9012-76-4 (Chitosan)
    • Publication Date:
      Date Created: 20130226 Date Completed: 20131028 Latest Revision: 20151119
    • Publication Date:
      20240829
    • Accession Number:
      23435397