Prenatal maternal mood is associated with altered diurnal cortisol in adolescence.

Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE

Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.

Affect* ; Prenatal Exposure Delayed Effects*; Adolescent/*physiology ; Anxiety/*physiopathology ; Circadian Rhythm/*physiology ; Depression/*physiopathology ; Hydrocortisone/*metabolism ; Hypothalamo-Hypophyseal System/*embryology ; Pituitary-Adrenal System/*embryology ; Pregnancy Complications/*physiopathology; Female ; Follow-Up Studies ; Humans ; Hydrocortisone/analysis ; Hypothalamo-Hypophyseal System/physiopathology ; Pituitary-Adrenal System/physiopathology ; Pregnancy ; Pregnancy Complications/psychology ; Saliva/chemistry ; Sampling Studies ; Secretory Rate ; Severity of Illness Index ; Socioeconomic Factors ; Wakefulness

Background: Experimental animal work shows that prenatal stress has a persisting effect on the hypothalamic-pituitary-adrenal (HPA) axis of offspring. The implications of these findings for human health and development are not yet clear.
Methods: The data are based on the ALSPAC cohort, a prospective longitudinal study of a community sample that has followed mothers and children from pregnancy. When the children were aged 15 years, diurnal cortisol samples were collected at wake-up, 30 min post-awakening and at afternoon and evening times on up to three consecutive days on n=889 adolescents. Diurnal cortisol was predicted from prenatal anxiety and depression, obstetric, life-style, socio-demographic, and postnatal covariates.
Results: Multilevel model analysis indicated that maternal prenatal anxiety was associated with a modest alteration of diurnal cortisol, indexed by a reduced cortisol awakening response and flatter diurnal slope. The effects were independent of psychosocial and obstetric covariates and measures of maternal postnatal anxiety; effects were similar for prenatal maternal depression. There was no association between adolescent cortisol and paternal prenatal anxiety.
Conclusions: There are small but persisting associations between maternal prenatal mood and diurnal cortisol in the child that persist into adolescence and may constitute a programming effect.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)

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092731 United Kingdom WT_ Wellcome Trust; 74882 United Kingdom MRC_ Medical Research Council; G9815508 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 076467 United Kingdom WT_ Wellcome Trust; R01 MH073842 United States MH NIMH NIH HHS

Keywords: ALSPAC; Cortisol; Developmental programming; HPA axis; Prenatal anxiety

WI4X0X7BPJ (Hydrocortisone)

Date Created: 20130226 Date Completed: 20140514 Latest Revision: 20240610

20240610

PMC3695029

10.1016/j.psyneuen.2013.01.008

23433748