Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Prognostic significance of heat shock proteins in urothelial carcinoma of the urinary bladder.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Yu HJ;Yu HJ; Chang YH; Pan CC
- Source:
Histopathology [Histopathology] 2013 Apr; Vol. 62 (5), pp. 788-98. Date of Electronic Publication: 2013 Feb 21.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE
- Publication Information:
Original Publication: Oxford, Blackwell Scientific Publications.
- Subject Terms:
- Abstract:
Aims: Heat shock proteins (HSPs) are a group of molecules induced by a variety of environmental and pathophysiological stresses, including cancer. The expression of HSPs has been implicated in the regulation of apoptosis and immunity in neoplasia. The purpose of this study was to evaluate the expression and clinicopathological relevance of several HSPs in urothelial carcinomas of the urinary bladder.
Methods and Results: Immunohistochemical staining for HSP27, HSP60, HSP70 and HSP90 was performed on samples collected from 744 clinical cases. The results were correlated with clinicopathological characteristics using univariate and multivariate analyses. High expression of HSP70 predicted recurrence of non-muscle-invasive urothelial carcinoma treated by transurethral resection, and low expression of HSP27 correlated with progression and cancer-specific mortality for non-muscle-invasive cancers treated by transurethral resection. Low expression of HSP27 also predicted cancer-specific mortality for patients who underwent cystectomy.
Conclusions: Both HSP27 and HSP70 impact on the biological behaviour of urothelial carcinomas of the urinary bladder. Immunohistochemical assessment of HSPs can provide useful prognostic information that could ultimately help to develop individualized surveillance programmes.
(© 2012 Blackwell Publishing Ltd.)
- Accession Number:
0 (Biomarkers, Tumor)
0 (HSP27 Heat-Shock Proteins)
0 (HSP70 Heat-Shock Proteins)
0 (HSPB1 protein, human)
0 (Heat-Shock Proteins)
0 (Molecular Chaperones)
- Publication Date:
Date Created: 20130222 Date Completed: 20130917 Latest Revision: 20201209
- Publication Date:
20231215
- Accession Number:
10.1111/his.12087
- Accession Number:
23425286
No Comments.