Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Source:
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
- Publication Information:
Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
- Subject Terms:
- Abstract:
Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell line. These compounds contain a positively charged quaternary amine functional group attached either directly to the glycerol backbone or at the end of an alkoxy chain. The biological testing has identified several analogues with activity equivalent to or greater than that exhibited by the reference compound in this assay, ET-18-OMe (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine). Among the most active analogues are compounds 11, [N,N,N-triethyl-3-(hexadecyloxy)-2-ethoxy-1-propylammonium bromide] and 22 [N-[4-[3-(hexadecyloxy)-2-ethoxypropoxy]-1-butyl]pyridinium bromide], which are approximately 3 times as active as the reference standard.
- Grant Information:
BRSG-RR 05404 United States RR NCRR NIH HHS; CA 41314 United States CA NCI NIH HHS; CA 42216 United States CA NCI NIH HHS
- Accession Number:
0 (Antineoplastic Agents)
0 (Ethers)
0 (Lipids)
0 (Pyridinium Compounds)
0 (Quaternary Ammonium Compounds)
EC 2.7.11.13 (Protein Kinase C)
- Publication Date:
Date Created: 19900601 Date Completed: 19900628 Latest Revision: 20190709
- Publication Date:
20231215
- Accession Number:
10.1021/jm00168a042
- Accession Number:
2342075
No Comments.