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High Helicobacter pylori resistance to metronidazole and clarithromycin in Brazilian children and adolescents.
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- Author(s): Ogata SK;Ogata SK; Godoy AP; da Silva Patricio FR; Kawakami E
- Source:
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2013 Jun; Vol. 56 (6), pp. 645-8.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8211545 Publication Model: Print Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE
- Publication Information:
Publication: 1998- : Philadelphia, PA : Lippincott Williams & Wilkins
Original Publication: [New York, N.Y.] : Raven Press, [c1982-
- Subject Terms:
- Abstract:
Objective: The aim of the present study was to assess the primary and secondary resistance of Helicobacter pylori strains to clarithromycin, amoxicillin, furazolidone, tetracycline, and metronidazole, the conventional antibiotics presently used in Brazilian children and adolescents.
Methods: Seventy-seven consecutive H pylori strains, 71 of 77 strains obtained from patients without previous eradication treatment for H pylori infection, and 6 strains from patients in whom previous eradication treatment had failed.
Results: Global rate of resistance was 49.3% (38/77): 40% of strains were resistant to metronidazole, 19.5% to clarithromycin, and 10.4% to amoxicillin. All of the tested H pylori strains were susceptible to furazolidone and tetracycline. Multiple resistance were detected in 18.2% (14/77 patients) of the strains: 6 of 14 (43%) simultaneously resistant to clarithromycin and metronidazole; 5 of 14 (36%) to amoxicillin and metronidazole; 2 of 14 (14%) to amoxicillin, clarithromycin, and metronidazole; and 1 of 14 (7%) to clarithromycin and amoxicillin.
Conclusions: The high resistance rate to metronidazole and clarithromycin observed in clinical H pylori isolates can exclude these antimicrobials in empirical eradication treatment in Brazil. Otherwise, furazolidone and tetracycline presented no resistance. Properly assessing the risks and benefits, these 2 antimicrobials and their derivatives could be used in empirical eradication schedules, both associated with amoxicillin, which showed a low resistance rate despite its wide use in pediatric patients.
- Accession Number:
0 (Anti-Bacterial Agents)
140QMO216E (Metronidazole)
5J9CPU3RE0 (Furazolidone)
804826J2HU (Amoxicillin)
F8VB5M810T (Tetracycline)
H1250JIK0A (Clarithromycin)
- Publication Date:
Date Created: 20130214 Date Completed: 20140110 Latest Revision: 20130529
- Publication Date:
20221213
- Accession Number:
10.1097/MPG.0b013e31828b3669
- Accession Number:
23403439
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