High mortality of pneumonia in cirrhotic patients with ascites.

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  • Author(s): Hung TH;Hung TH; Tseng CW; Hsieh YH; Tseng KC; Tsai CC; Tsai CC
  • Source:
    BMC gastroenterology [BMC Gastroenterol] 2013 Feb 07; Vol. 13, pp. 25. Date of Electronic Publication: 2013 Feb 07.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Ascites/*epidemiology ; Ascites/*mortality ; Liver Cirrhosis/*epidemiology ; Liver Cirrhosis/*mortality ; Pneumonia/*epidemiology ; Pneumonia/*mortality; Adult ; Aged ; Comorbidity ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; Peritonitis/epidemiology ; Peritonitis/mortality ; Prevalence ; Retrospective Studies ; Risk Factors ; Survival Rate ; Taiwan/epidemiology ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/mortality
    • Abstract:
      Background: Cirrhotic patients with ascites are prone to develop various infectious diseases. This study aimed to evaluate the occurrence and effect of major infectious diseases on the mortality of cirrhotic patients with ascites.
      Methods: We reviewed de-identified patient data from the National Health Insurance Database, derived from the Taiwan National Health Insurance Program, to enroll 4,576 cirrhotic patients with ascites, who were discharged from Taiwan hospitals between January 1, 2004 and June 30, 2004. We collected patients' demographic and clinical data, and reviewed diagnostic codes to determine infectious diseases and comorbid disorders of their hospitalizations. Patients were divided into an infection group and non-infection group and hazard ratios (HR) were determined for specific infectious diseases.
      Results: Of the total 4,576 cirrhotic patients with ascites, 1,294 (28.2%) were diagnosed with infectious diseases during hospitalization. The major infectious diseases were spontaneous bacterial peritonitis (SBP) (645, 49.8%), urinary tract infection (151, 11.7%), and pneumonia (100, 7.7%). After adjusting for patients' age, gender, and other comorbid disorders, the HRs of infectious diseases for 30-day and 90-day mortality of cirrhotic patients with ascites were 1.81 (1.54-2.11) and 1.60 (1.43-1.80) respectively, compared to those in the non-infection group. The adjusted HRs of pneumonia, urinary tract infection (UTI), spontaneous bacterial peritonitis (SBP), and sepsis without specific focus (SWSF) were 2.95 (2.05-4.25), 1.32 (0.86-2.05), 1.77 (1.45-2.17), and 2.19 (1.62-2.96) for 30-day mortality, and 2.57 (1.93-3.42), 1.36 (1.01-1.82), 1.51 (1.29-1.75), and 2.13 (1.70-2.66) for 90-day mortality, compared to those in the non-infection group.
      Conclusion: Infectious diseases increased 30-day and 90-day mortality of cirrhotic patients with ascites. Among all infectious diseases identified, pneumonia carried the highest risk for mortality.
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    • Publication Date:
      Date Created: 20130209 Date Completed: 20130910 Latest Revision: 20220410
    • Publication Date:
      20221213
    • Accession Number:
      PMC3599048
    • Accession Number:
      10.1186/1471-230X-13-25
    • Accession Number:
      23390924