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Balanced Tiam1-rac1 and RhoA drives proliferation and invasion of pancreatic cancer cells.
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- Author(s): Guo X;Guo X; Wang M; Jiang J; Xie C; Peng F; Li X; Tian R; Qin R
- Source:
Molecular cancer research : MCR [Mol Cancer Res] 2013 Mar; Vol. 11 (3), pp. 230-9. Date of Electronic Publication: 2013 Jan 15.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
- Publication Information:
Original Publication: Philadelphia, PA : American Association for Cancer Research, c2002-
- Subject Terms:
- Abstract:
Tiam1 is a rac1-specific guanine nucleotide exchange factor, and Tiam1-rac1 is involved in a number of cellular processes. Rac1 and RhoA act as molecular switches that cycle between GTP- and GDP-bound states to balance the activities of rac1 and RhoA. The downregulation of rac1 activity leads to upregulation of RhoA activity, which promotes invasion and migration of pancreatic cancers cells. At present, however, the role of Tiam1-rac1 and RhoA in pancreatic cancers is not fully understood. We found that Tiam1 was upregulated in pancreatic cancers and was significantly expressed in tumors without lymph node involvement or distant metastasis compared with cancers where there was involvement. Although Tiam1-rac1 signaling promoted pancreatic cancer cell proliferation and tumor growth via the Wnt signaling pathway in vitro and in vivo, inhibiting Tiam1-rac1 signaling did not prolong the overall survival time in vivo. This provided evidence that there was a balance between rac1 and RhoA activities in pancreatic cancers. Furthermore, only the combined inhibition of Tiam1-rac1 and RhoA had a beneficial effect on the growth of pancreatic cancers in vivo. Taken together, these results suggest that the progression of pancreatic tumors is partially controlled by the balance between Tiam1-rac1 and RhoA.
- Comments:
Erratum in: Mol Cancer Res. 2022 Dec 2;20(12):1822. (PMID: 36458417)
- Accession Number:
0 (Guanine Nucleotide Exchange Factors)
0 (RAC1 protein, human)
0 (T-Lymphoma Invasion and Metastasis-inducing Protein 1)
0 (TIAM1 protein, human)
124671-05-2 (RHOA protein, human)
EC 3.6.5.2 (rac1 GTP-Binding Protein)
EC 3.6.5.2 (rhoA GTP-Binding Protein)
- Publication Date:
Date Created: 20130117 Date Completed: 20130903 Latest Revision: 20221202
- Publication Date:
20240829
- Accession Number:
10.1158/1541-7786.MCR-12-0632
- Accession Number:
23322732
No Comments.