[Prevalence of mutations responsible for resistance to antiretroviral preparations among HIV-1 variants circulating in Novosibirsk region].

Publisher: FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Country of Publication: Russia (Federation) NLM ID: 0415217 Publication Model: Print Cited Medium: Print ISSN: 0372-9311 (Print) Linking ISSN: 03729311 NLM ISO Abbreviation: Zh Mikrobiol Epidemiol Immunobiol Subsets: MEDLINE

Publication: <2018, no. 4 (ii︠u︡lʹ-avgust)- >: Moskva : FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora
Original Publication: Moskva : Izd-vo "Medit︠s︡ina"

Genes, pol* ; Mutation*; Anti-HIV Agents/*therapeutic use ; Drug Resistance, Viral/*genetics ; HIV Infections/*epidemiology ; HIV-1/*genetics ; Reverse Transcriptase Inhibitors/*pharmacology; Adult ; Algorithms ; Anti-HIV Agents/administration & dosage ; Antiretroviral Therapy, Highly Active ; Child ; Drug Resistance, Viral/drug effects ; Genotype ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV-1/drug effects ; HIV-1/isolation & purification ; Humans ; Molecular Typing ; Prevalence ; Sequence Analysis, DNA ; Siberia/epidemiology ; Virus Replication/drug effects

Aim: Analyze the diversity and prevalence of mutations in human immunodeficiency virus type 1 (HIV-1) genome emerging in response to antiretroviral therapy isolated from HIV-infected individuals of Novosibirsk region in 2010, 2011.
Materials and Methods: Detection of mutations in HIV-1 genome responsible for the resistance to. antiretroviral preparations (ARVP) was carried out by determination of pol gene nucleotide sequence and subsequent analysis ofthe data obtained by program HIVdb: Genotypic Resistance Interpretation Algorithm.
Results: HIV-1 resistance mutations to antiretroviral preparations were detected in 23.6% of the total number of the studied samples. The most prevalent mutations are those conditioning resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (M184V, Y181C and K103N). In studies of HIV-1 isolated from 4 patients who had not received antiretroviral therapy (ARVT) transmission of HIV-1 resistant to various groups of preparations was detected.
Conclusion: The detected facts of ARVP resistant HIV-1 circulation among patients who had not received ARVT and the data obtained on the mutations emerging in response to therapy underline the relevance of administration of HIV-1 resistance profile study during both decrease of ARVT effectiveness and primary administration of therapy to HIV infected patients.

0 (Anti-HIV Agents)
0 (Reverse Transcriptase Inhibitors)
EC 2.7.7.49 (HIV Reverse Transcriptase)

Date Created: 20130110 Date Completed: 20130122 Latest Revision: 20200716

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