Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene.

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  • Additional Information
    • Source:
      Publisher: College of American Pathologists Country of Publication: United States NLM ID: 7607091 Publication Model: Print Cited Medium: Internet ISSN: 1543-2165 (Electronic) Linking ISSN: 00039985 NLM ISO Abbreviation: Arch Pathol Lab Med Subsets: MEDLINE
    • Publication Information:
      Publication: Northfield, Ill. : College of American Pathologists
      Original Publication: Chicago, American Medical Assn.
    • Subject Terms:
      Genes, myc*; Burkitt Lymphoma/*genetics ; Burkitt Lymphoma/*pathology ; Proto-Oncogene Proteins c-ets/*genetics ; Repressor Proteins/*genetics ; Waldenstrom Macroglobulinemia/*genetics ; Waldenstrom Macroglobulinemia/*pathology; Aged ; Cytogenetic Analysis ; Female ; Gene Deletion ; Gene Rearrangement, B-Lymphocyte ; Genes, Tumor Suppressor ; Humans ; In Situ Hybridization, Fluorescence ; Time Factors ; Translocation, Genetic ; ETS Translocation Variant 6 Protein
    • Abstract:
      Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with variable plasmacytic differentiation that displays an indolent clinical course. Its transformation to a high-grade B-cell lymphoma may occur uncommonly. Although acquisition of a MYC translocation could result in transformation of a low-grade lymphoma into diffuse large B-cell lymphoma, Burkitt lymphoma, or B-lymphoblastic leukemia, to our knowledge the latter 2 transformations have not been well documented in lymphoplasmacytic lymphoma. We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma.
    • Accession Number:
      0 (Proto-Oncogene Proteins c-ets)
      0 (Repressor Proteins)
    • Publication Date:
      Date Created: 20130102 Date Completed: 20130225 Latest Revision: 20231213
    • Publication Date:
      20231215
    • Accession Number:
      10.5858/arpa.2011-0429-CR
    • Accession Number:
      23276184