Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions.

Publisher: Springer Country of Publication: Austria NLM ID: 9806853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-6102 (Electronic) Linking ISSN: 0033183X NLM ISO Abbreviation: Protoplasma Subsets: MEDLINE

Publication: <1998->: Wien ; New York : Springer
Original Publication: Leipzig : Verlag von Gebrüder Borntraeger, 1927-

Mechanotransduction, Cellular*; Cadherins/*physiology ; Cell Adhesion/*physiology ; Cytoskeleton/*physiology ; Intercellular Junctions/*physiology ; Vinculin/*physiology; Amino Acid Sequence ; Animals ; Cadherins/chemistry ; Cadherins/metabolism ; Conserved Sequence ; Cytoskeleton/metabolism ; Humans ; Intercellular Junctions/metabolism ; Molecular Sequence Data ; Sequence Homology, Amino Acid ; Signal Transduction ; Vinculin/chemistry ; Vinculin/metabolism

Cell adhesion junctions characteristically arise from the cooperative integration of adhesion receptors, cell signalling pathways and the cytoskeleton. This is exemplified by cell-cell interactions mediated by classical cadherin adhesion receptors. These junctions are sites where cadherin adhesion systems functionally couple to the dynamic actin cytoskeleton, a process that entails physical interactions with many actin regulators and regulation by cell signalling pathways. Such integration implies a potential role for molecules that may stand at the interface between adhesion, signalling and the cytoskeleton. One such candidate is the cortical scaffolding protein, vinculin, which is a component of both cell-cell and cell-matrix adhesions. While its contribution to integrin-based adhesions has been extensively studied, less is known about how vinculin contributes to cell-cell adhesions. A major recent advance has come with the realisation that cadherin adhesions are active mechanical structures, where cadherin serves as part of a mechanotransduction pathway by which junctions sense and elicit cellular responses to mechanical stimuli. Vinculin has emerged as an important element in cadherin mechanotransduction, a perspective that illuminates its role in cell-cell interactions. We now review its role as a cortical scaffold and its role in cadherin mechanotransduction.

Erratum in: Protoplasma. 2013 Aug;250(4):831.

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0 (Cadherins)
125361-02-6 (Vinculin)

Date Created: 20130101 Date Completed: 20140513 Latest Revision: 20211021

20221213

10.1007/s00709-012-0475-6

23274283