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Adipocytokines, hepatic and inflammatory biomarkers and incidence of type 2 diabetes. the CoLaus study.
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- Author(s): Marques-Vidal P;Marques-Vidal P; Schmid R; Bochud M; Bastardot F; von Känel R; Paccaud F; Glaus J; Preisig M; Waeber G; Vollenweider P
- Source:
PloS one [PLoS One] 2012; Vol. 7 (12), pp. e51768. Date of Electronic Publication: 2012 Dec 12.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Adipokines/*blood ; Biomarkers/*blood ; Diabetes Mellitus, Type 2/*blood ; Diabetes Mellitus, Type 2/*epidemiology ; Inflammation/*pathology ; Liver/*metabolism ; Liver/*pathology; Adult ; Aged ; Diabetes Mellitus, Type 2/pathology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Risk Factors ; Switzerland/epidemiology
- Abstract: Context: There is contradictory information regarding the prognostic importance of adipocytokines, hepatic and inflammatory biomarkers on the incidence of type 2 diabetes. The objective was to assess the prognostic relevance of adipocytokine and inflammatory markers (C-reactive protein - CRP; interleukin-1beta - IL-1β; interleukin-6- IL-6; tumour necrosis factor-α - TNF-α; leptin and adiponectin) and gamma-glutamyl transpeptidase (γGT) on the incidence of type 2 diabetes.
Methods: Prospective, population-based study including 3,842 non-diabetic participants (43.3% men, age range 35 to 75 years), followed for an average of 5.5 years (2003-2008). The endpoint was the occurrence of type 2 diabetes.
Results: 208 participants (5.4%, 66 women) developed type 2 diabetes during follow-up. On univariate analysis, participants who developed type 2 diabetes had significantly higher baseline levels of IL-6, CRP, leptin and γGT, and lower levels of adiponectin than participants who remained free of type 2 diabetes. After adjusting for a validated type 2 diabetes risk score, only the associations with adiponectin: Odds Ratio and (95% confidence interval): 0.97 (0.64-1.47), 0.84 (0.55-1.30) and 0.64 (0.40-1.03) for the second, third and forth gender-specific quartiles respectively, remained significant (P-value for trend = 0.05). Adding each marker to a validated type 2 diabetes risk score (including age, family history of type 2 diabetes, height, waist circumference, resting heart rate, presence of hypertension, HDL cholesterol, triglycerides, fasting glucose and serum uric acid) did not improve the area under the ROC or the net reclassification index; similar findings were obtained when the markers were combined, when the markers were used as continuous (log-transformed) variables or when gender-specific quartiles were used.
Conclusion: Decreased adiponectin levels are associated with an increased risk for incident type 2 diabetes, but they seem to add little information regarding the risk of developing type 2 diabetes to a validated risk score. - References: PLoS One. 2011;6(6):e19852. (PMID: 21674000)
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PLoS One. 2010 Apr 09;5(4):e10100. (PMID: 20396381) - Accession Number: 0 (Adipokines)
0 (Biomarkers) - Publication Date: Date Created: 20121220 Date Completed: 20130603 Latest Revision: 20220317
- Publication Date: 20231215
- Accession Number: PMC3520903
- Accession Number: 10.1371/journal.pone.0051768
- Accession Number: 23251619
- Source:
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