[Study on the immunocompetence of polysaccharide extracted from root of Salvia miltiorrhiza].

Publisher: Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan Country of Publication: China NLM ID: 9426370 Publication Model: Print Cited Medium: Print ISSN: 1001-4454 (Print) Linking ISSN: 10014454 NLM ISO Abbreviation: Zhong Yao Cai Subsets: MEDLINE

Publication: Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan
Original Publication: Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan,

Hypersensitivity, Delayed/*immunology ; Immunocompetence/*drug effects ; Lymphocytes/*drug effects ; Polysaccharides/*pharmacology ; Salvia miltiorrhiza/*chemistry; Animals ; Dinitrofluorobenzene/administration & dosage ; Disease Models, Animal ; Gene Expression Regulation ; Hypersensitivity, Delayed/chemically induced ; Hypersensitivity, Delayed/pathology ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Lipopolysaccharides/administration & dosage ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/immunology ; Lymphocytes/immunology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/immunology ; Male ; Mice ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism ; Phagocytosis/drug effects ; Phagocytosis/immunology ; Plant Roots/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Spleen/drug effects ; Spleen/immunology

Objective: To study the immune activity of polysaccharide extracted from root of Salvia miltiorrhiza.
Methods: Investigated the effects of polysaccharide extracted from root of Salvia miltiorrhiza on lymphocyte proliferation response of mouse induced by LPS (the lipopolysaccharide LPS), phagocytosis of the peritoneal macrophage of mice to chick erythrocytes and the mouse models of delayed type hypersensitivity (DTH) response induced by DNFB.
Results: Lymphocyte proliferation and phagocytosis of the peritoneal macrophage of mice could be promoted by the polysaccharide, which could inhibit ear edema and capillary permeability increase induced by DNFB and enlarged the thymus and splenic index in mice. The expression of iNOS, IFN-alpha and IL-1beta was inhibited significantly in the treatment group.
Conclusion: The polysaccharide extracted from Salvia miltiorrhiza can improve immune function.

0 (Lipopolysaccharides)
0 (Polysaccharides)
0 (RNA, Messenger)
82115-62-6 (Interferon-gamma)
D241E059U6 (Dinitrofluorobenzene)
EC 1.14.13.39 (Nitric Oxide Synthase)

Date Created: 20121215 Date Completed: 20130312 Latest Revision: 20131121

20240829

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