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Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis.
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- Author(s): Albrecht E;Albrecht E; Kirkham KR; Liu SS; Brull R
- Source:
Anaesthesia [Anaesthesia] 2013 Jan; Vol. 68 (1), pp. 79-90. Date of Electronic Publication: 2012 Nov 01.
- Publication Type:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review
- Language:
English
- Additional Information
- Source:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0370524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2044 (Electronic) Linking ISSN: 00032409 NLM ISO Abbreviation: Anaesthesia Subsets: MEDLINE
- Publication Information:
Publication: Oxford, UK : Wiley-Blackwell
Original Publication: London, Academic Press; New York, Grune & Stratton.
- Subject Terms:
- Abstract:
Intravenous magnesium has been reported to improve postoperative pain; however, the evidence is inconsistent. The objective of this quantitative systematic review is to evaluate whether or not the peri-operative administration of intravenous magnesium can reduce postoperative pain. Twenty-five trials comparing magnesium with placebo were identified. Independent of the mode of administration (bolus or continuous infusion), peri-operative magnesium reduced cumulative intravenous morphine consumption by 24.4% (mean difference: 7.6 mg, 95% CI -9.5 to -5.8 mg; p < 0.00001) at 24 h postoperatively. Numeric pain scores at rest and on movement at 24 h postoperatively were reduced by 4.2 (95% CI -6.3 to -2.1; p < 0.0001) and 9.2 (95% CI -16.1 to -2.3; p = 0.009) out of 100, respectively. We conclude that peri-operative intravenous magnesium reduces opioid consumption, and to a lesser extent, pain scores, in the first 24 h postoperatively, without any reported serious adverse effects.
(Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.)
- Comments:
Comment in: Anaesthesia. 2013 Aug;68(8):875-6. (PMID: 24044451)
- Accession Number:
0 (Analgesics, Opioid)
7487-88-9 (Magnesium Sulfate)
76I7G6D29C (Morphine)
- Publication Date:
Date Created: 20121106 Date Completed: 20130205 Latest Revision: 20220409
- Publication Date:
20221213
- Accession Number:
10.1111/j.1365-2044.2012.07335.x
- Accession Number:
23121612
No Comments.