The alpha-neurotoxin erabutoxin b causes fade at the rat end-plate.

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  • Author(s): Bradley RJ;Bradley RJ; Edge MT; Chau WC
  • Source:
    European journal of pharmacology [Eur J Pharmacol] 1990 Jan 25; Vol. 176 (1), pp. 11-21.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Amsterdam : Elsevier Science
      Original Publication: Amsterdam, North Holland Pub. Co.
    • Subject Terms:
      Elapid Venoms/*pharmacology ; Erabutoxins/*pharmacology ; Motor Endplate/*drug effects ; Neuromuscular Junction/*drug effects; Action Potentials/drug effects ; Animals ; Electric Stimulation ; In Vitro Techniques ; Male ; Muscle Contraction/drug effects ; Rats ; Respiratory Muscles/drug effects ; Respiratory Muscles/physiology ; Tubocurarine/pharmacology
    • Abstract:
      d-Tubocurarine and the alpha-neurotoxins from snake venom are antagonists at the nicotinic acetylcholine receptor. It is well established that d-tubocurarine causes fade in neuromuscular transmission during repetitive nerve stimulation but paradoxically there are many reports which indicate that the alpha-neurotoxins do not cause such fade. We found that high concentrations of erabutoxin b (100-150 nM) from the venom of Laticauda semifasciata did not cause much fade in the rat diaphragm preparation. However, low concentrations of toxin (5 nM) caused severe fade which was similar to the effects of d-tubocurarine. The data suggest that fade may be caused by toxin binding to a high-affinity site on the postsynaptic acetylcholine receptor.
    • Grant Information:
      ES04295 United States ES NIEHS NIH HHS; MH39115 United States MH NIMH NIH HHS
    • Accession Number:
      0 (Elapid Venoms)
      59536-69-5 (Erabutoxins)
      9083-23-2 (erabutoxin b)
      W9YXS298BM (Tubocurarine)
    • Publication Date:
      Date Created: 19900125 Date Completed: 19900418 Latest Revision: 20190624
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/0014-2999(90)90127-r
    • Accession Number:
      2311657