Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print Cited Medium: Print ISSN: 0024-3205 (Print) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.

Tetrahydroisoquinolines*; Brain/*metabolism ; Debrisoquin/*metabolism ; Isoquinolines/*metabolism ; Parkinson Disease/*etiology; Animals ; Chemical Phenomena ; Chemistry ; Disease Models, Animal ; Female ; Gas Chromatography-Mass Spectrometry ; Isoquinolines/analysis ; Isoquinolines/urine ; Male ; Microsomes, Liver/analysis ; Rats ; Rats, Inbred Strains

4-Hydroxytetrahydroisoquinoline (4OH-TIQ) was detected as a metabolite of a possible parkinsonism-inducing substance, tetrahydroisoquinoline (TIQ), in rat liver microsomes and rat urine. Urinary excretion of 4OH-TIQ was significantly reduced in female DA rat, an animal model of a poor debrisoquine metabolizer. The female DA rat also showed significantly higher brain accumulation of TIQ. These results suggest that the metabolic detoxication process is depressed and TIQ accumulation in the brain is enhanced in a poor debrisoquine metabolizer, which may be one possible explanation for poor debrisoquine metabolizers being susceptible to Parkinson's disease.

0 (Isoquinolines)
0 (Tetrahydroisoquinolines)
56W89FBX3E (1,2,3,4-tetrahydroisoquinoline)
X31CDK040E (Debrisoquin)

Date Created: 19900101 Date Completed: 19900406 Latest Revision: 20190701

20221213

10.1016/0024-3205(90)90128-e

2308469