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Change of plasma osteoprotegerin and its association with endothelial dysfunction before and after exercise in Hashimoto's thyroiditis with euthyroidism.
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- Author(s): Xiang G;Xiang G; Xiang L; Xiang L; Wang H; Dong J
- Source:
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2012 Oct; Vol. 120 (9), pp. 529-34. Date of Electronic Publication: 2012 Oct 15.
- Publication Type:
Clinical Trial; Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: J.A. Barth Country of Publication: Germany NLM ID: 9505926 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3646 (Electronic) Linking ISSN: 09477349 NLM ISO Abbreviation: Exp Clin Endocrinol Diabetes Subsets: MEDLINE
- Publication Information:
Original Publication: Heidelberg : J.A. Barth, c1995-
- Subject Terms:
- Abstract:
Objective: Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicated that OPG also acts as an important regulatory molecule in the vasculature. The purpose of this study was to investigate the change of OPG and its associations with endothelial function before and after exercise training in Hashimoto's thyroiditis (HT) with euthyroidism.The study subjects included 62 newly diagnosed sedentary Chinese Han HT women with euthyroidism and 28 sedentary Chinese Han female healthy subjects. All individuals participated in an exercise training of 6 months. Plasma OPG concentrations were measured in duplicate by a sandwich enzyme-linked immunosorbent assay, and high resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia, and after sublingual glyceryltrinitrate.
Results: The OPG concentration in HT patients with euthyroidism before exercise was 3.0±0.81 ng/L, which was significantly higher than that in control subjects (2.44±0.24 ng/L, p<0.001). After 6 months of exercise, OPG levels decreased markedly (2.40±0.61 ng/L, p<0.001). Flow-mediated dilation (FMD) in HT patients with euthyroidism before exercise was 4.06±0.78%, which was significantly lower than that in control subjects (5.54±0.61%, p<0.001), and it improved markedly after 6 months of exercise (5.0±0.79, p<0.001). The absolute changes in OPG showed significant correlation with the changes in FMD (r= - 0.432, p=0.001), TBARS (r= - 0.370, p=0.004) and CRP (r= - 0.503, p<0.001).
Conclusion: The current study demonstrates that plasma OPG levels increased significantly at baseline, decreased dramatically after 6 months regular aerobic exercise training, and are correlated with endothelium-dependent arterial dilation in HT patients with euthyroidism.
(© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.)
- Accession Number:
0 (Osteoprotegerin)
0 (TNFRSF11B protein, human)
0 (Thyroid Hormones)
0 (Vasodilator Agents)
9007-41-4 (C-Reactive Protein)
- Publication Date:
Date Created: 20121017 Date Completed: 20130312 Latest Revision: 20221207
- Publication Date:
20240829
- Accession Number:
10.1055/s-0032-1323806
- Accession Number:
23070830
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