Short-spaced dipole for managing phrenic nerve stimulation in patients with CRT: the "phrenic nerve mapping and stimulation EP" catheter study.

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  • Additional Information
    • Corporate Authors:
      PING-EP Study Group
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Elsevier, c2004-
    • Subject Terms:
      Cardiac Resynchronization Therapy/*methods ; Heart Ventricles/*physiopathology ; Phrenic Nerve/*physiopathology ; Ventricular Dysfunction, Left/*physiopathology; Aged ; Analysis of Variance ; Cardiac Resynchronization Therapy Devices ; Chi-Square Distribution ; Coronary Angiography ; Electrodes, Implanted ; Female ; Humans ; Italy ; Male ; Statistics, Nonparametric
    • Abstract:
      Background: Phrenic nerve stimulation (PNS), occurring in 33%-37% of the patients with cardiac resynchronization therapy (CRT), is a limiting factor when implanting left ventricular (LV) leads from coronary veins.
      Objective: To test the hypothesis that PNS occurrence is related to bipolar electrode spacing.
      Methods: During standard CRT defibrillator implant procedures, a 5-F diagnostic electrophysiology catheter with 10 electrodes, spaced 2-5-2 mm, was positioned in a cardiac vein suitable for permanent LV lead placement. Pacing in the unipolar configuration identified the site with the lowest PNS threshold. PNS and left ventricular pacing (LVP) thresholds were then measured in different configurations at 0.5 ms: unipolar, each LV electrode served as the cathode in turn; and bipolar with different electrode spacing, cathode being the electrode with the lowest unipolar PNS threshold.
      Results: From February to September 2010, 40 patients undergoing CRT implantation were enrolled in 4 centers in Italy. It was possible to identify PNS and perform a complete set of measurements in 23 patients. A bipolar electrode spacing of 2 mm resulted in higher PNS thresholds in bipolar configurations han did a bipolar electrode spacing of ≥ 5 mm. However, no significant increase in the LVP threshold was observed (P = ns).
      Conclusions: This experience suggests that LVP with a bipolar electrode spacing of 2 mm significantly increases the PNS threshold without affecting the LVP threshold, thereby increasing the possibility of delivering CRT when the LV lead is placed in proximity to the phrenic nerve.
      (Copyright © 2013 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Investigator: P Battistini; M Biffi; G Boriani; I Diemberger; C Martignani; M Ziacchi; E Baracca; G Pastore; F Zanon; F Zerbo; E Bertaglia; F Zoppo; L Padeletti; L Perrotta; P Pieragnoli; G Ricciardi; T De Santo; A Varbaro; Z Yang
    • Publication Date:
      Date Created: 20121016 Date Completed: 20130620 Latest Revision: 20161222
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.hrthm.2012.08.045
    • Accession Number:
      23063865