Imaging of localized retinal nerve fiber layer defects in preperimetric glaucoma using spectral-domain optical coherence tomography.

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  • Additional Information
    • Source:
      Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
    • Publication Information:
      Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
      Original Publication: New York, N.Y. : Raven Press, c1992-
    • Subject Terms:
      Tonometry, Ocular*; Glaucoma/*diagnosis ; Nerve Fibers/*pathology ; Optic Disk/*pathology ; Optic Nerve Diseases/*diagnosis ; Retinal Ganglion Cells/*pathology; Adult ; Aged ; Cross-Sectional Studies ; Female ; Healthy Volunteers ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Visual Field Tests ; Visual Fields/physiology
    • Abstract:
      Purpose: To characterize preperimetric retinal nerve fiber layer (RNFL) defects on speckle noise-reduced spectral-domain optical coherence tomography (SD-OCT), and to determine whether detection of preperimetric RNFL defects can be improved by speckle noise reduction.
      Patients and Methods: Thirty-two eyes of 32 patients with preperimetric glaucoma and 30 normal eyes of 30 volunteers underwent complete ophthalmic examinations and scanning by speckle noise-reduced SD-OCT (Spectralis), single-scan SD-OCT (RTVue-100), and single-scan time-domain (Stratus) OCT.
      Results: All 40 RNFL defects identified by photography had angular widths <30 degrees and no disruption of RNFL reflectivity on Spectralis. Circumpapillary RNFL (cpRNFL) boundaries were accurately determined by Spectralis for 38 (95.0%) of the 40 defects, by RTVue-100 for 25 (62.5%), and by Stratus OCT for 23 (57.5%). Sensitivity for the detection of RNFL defects (cpRNFL thinning to <1% of normal for an age-matched database) was 15% for Stratus, 42.5% for RTVue, and 47.5% for Spectralis on sector maps and significantly higher for SD-OCT on temporal-superior-nasal-inferior-temporal (TSNIT) thickness graphs: RTVue-100 (57.5%; P=0.031) and Spectralis (90.0%; P=0.0001). On the basis of TSNIT thickness graphs, sensitivity for the detection of RNFL defects was significantly higher for Spectralis compared with RTVue-100 (P=0.001) and Stratus (P=0.0005). Spectralis TSNIT graphs were more sensitive (P=0.001) for glaucoma detection without significant reduction (P=0.125) in specificity compared with Spectralis sector maps.
      Conclusions: Our results suggest that accurate measurement of cpRNFL thickness by speckle noise-reduced SD-OCT and a comparison of the results with normative database using TSNIT graphs are required to improve the sensitivity for detecting preperimetric RNFL defects.
    • Publication Date:
      Date Created: 20121013 Date Completed: 20140805 Latest Revision: 20140303
    • Publication Date:
      20231215
    • Accession Number:
      10.1097/IJG.0b013e3182707456
    • Accession Number:
      23059486