Membrane resonance enables stable and robust gamma oscillations.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE

Original Publication: New York, NY : Oxford University Press, c1991-

Electroencephalography*; Beta Rhythm/*physiology; Algorithms ; Animals ; Cats ; Computer Simulation ; Cortical Synchronization ; Electrophysiological Phenomena ; Interneurons/physiology ; Neural Networks, Computer ; Neural Pathways/physiology ; Photic Stimulation ; Pyramidal Cells/physiology ; Reproducibility of Results ; Synapses/physiology ; Visual Cortex/physiology

Neuronal mechanisms underlying beta/gamma oscillations (20-80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate dramatically. Enhanced frequency stability is associated with stronger oscillations measured in individual units and larger power in the local field potential. Simulations of neuronal circuitry demonstrate that membrane properties of inhibitory interneurons strongly determine the characteristics of emergent oscillations. Exploration of networks containing either integrator or resonator inhibitory interneurons revealed that: (i) Resonance, as opposed to integration, promotes robust oscillations with large power and stable frequency via a mechanism called RING (Resonance INduced Gamma); resonance favors synchronization by reducing phase delays between interneurons and imposes bounds on oscillation cycle duration; (ii) Stability of frequency and robustness of the oscillation also depend on the relative timing of excitatory and inhibitory volleys within the oscillation cycle; (iii) RING can reproduce characteristics of both Pyramidal INterneuron Gamma (PING) and INterneuron Gamma (ING), transcending such classifications; (iv) In RING, robust gamma oscillations are promoted by slow but are impaired by fast inputs. Results suggest that interneuronal membrane resonance can be an important ingredient for generation of robust gamma oscillations having stable frequency.

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Keywords: ING; PING; RING; oscillation frequency; visual cortex

Date Created: 20121009 Date Completed: 20140925 Latest Revision: 20220309

20240628

PMC3862267

10.1093/cercor/bhs293

23042733