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Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus.
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- Author(s): Kothny W;Kothny W; Foley J; Kozlovski P; Shao Q; Gallwitz B; Lukashevich V
- Source:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2013 Mar; Vol. 15 (3), pp. 252-7. Date of Electronic Publication: 2012 Nov 01.- Publication Type:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
- Publication Information: Original Publication: Oxford : Wiley-Blackwell, c1999-
- Subject Terms: Adamantane/*analogs & derivatives ; Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*drug therapy ; Glycated Hemoglobin/*metabolism ; Hypoglycemic Agents/*pharmacology ; Insulin/*metabolism ; Metformin/*pharmacology ; Nitriles/*pharmacology ; Pyrrolidines/*pharmacology; Adamantane/administration & dosage ; Adamantane/pharmacology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asia/epidemiology ; Australia/epidemiology ; Blood Glucose/drug effects ; Body Weight/drug effects ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Europe/epidemiology ; Female ; Glucose Tolerance Test ; Glycated Hemoglobin/drug effects ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin Secretion ; Male ; Metformin/administration & dosage ; Middle Aged ; Nitriles/administration & dosage ; Pyrrolidines/administration & dosage ; Treatment Outcome ; United States/epidemiology ; Vildagliptin
- Abstract: Aim: The aim of this study is to assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in type 2 diabetes mellitus (T2DM).
Methods: This is a multicentre, double-blind, placebo-controlled, parallel group, clinical trial in T2DM patients inadequately controlled by stable insulin therapy, with or without metformin. Patients received treatment with vildagliptin 50 mg bid or placebo for 24 weeks.
Results: In all, 449 patients were randomized to vildagliptin (n = 228) or placebo (n = 221). After 24 weeks, the difference in adjusted mean change in haemoglobin A1c (HbA1c) between vildagliptin and placebo was -0.7 ± 0.1% (p < 0.001) in the overall study population, -0.6 ± 0.1% (p < 0.001) in the subgroup also receiving metformin and -0.8 ± 0.2% (p < 0.001) in the subgroup without metformin. Vildagliptin therapy was well tolerated and had a similarly low incidence of hypoglycaemia compared with placebo (8.4 vs. 7.2%, p = 0.66) in spite of improved glycaemic control, and was not associated with weight gain. (+0.1 vs. -0.4 kg).
Conclusions: Vildagliptin 50 mg bid added to insulin significantly reduced HbA1c in patients with T2DM inadequately controlled by insulin, with or without metformin. Vildagliptin was well tolerated, with a safety profile similar to placebo. These results were achieved without weight gain or an increase in hypoglycaemia incidence or severity in spite of improved glycaemic control.
(© 2012 Blackwell Publishing Ltd.) - Accession Number: 0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (Hypoglycemic Agents)
0 (Insulin)
0 (Nitriles)
0 (Pyrrolidines)
0 (hemoglobin A1c protein, human)
9100L32L2N (Metformin)
I6B4B2U96P (Vildagliptin)
PJY633525U (Adamantane) - Publication Date: Date Created: 20121009 Date Completed: 20130802 Latest Revision: 20221207
- Publication Date: 20240628
- Accession Number: 10.1111/dom.12020
- Accession Number: 23039321
- Source:
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