Anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats.

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  • Author(s): Bidkar JS;Bidkar JS; Ghanwat DD; Bhujbal MD; Dama GY
  • Source:
    Journal of complementary & integrative medicine [J Complement Integr Med] 2012 Sep 24; Vol. 9, pp. Article 22. Date of Electronic Publication: 2012 Sep 24.
  • Publication Type:
    Evaluation Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: Electronic Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE
    • Publication Information:
      Publication: <2012-> : Berlin : Walter de Gruyter
      Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004-
    • Subject Terms:
      Cucumis melo* ; Phytotherapy*; Hyperlipidemias/*drug therapy ; Hypolipidemic Agents/*therapeutic use ; Plant Extracts/*therapeutic use; Administration, Oral ; Animals ; Biomarkers/blood ; Cholesterol, Dietary ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Diet, High-Fat ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Fruit ; Hyperlipidemias/blood ; Hyperlipidemias/etiology ; India ; Male ; Medicine, Traditional ; Plants, Medicinal ; Rats ; Rats, Wistar ; Treatment Outcome ; Triglycerides/blood
    • Abstract:
      Abstract Cucumis melo Linn. (Cucurbitaceae) fruits have been used, traditionally in Indian traditional system of medicine, for the treatment of various disorders such as liver tonic, cardioprotective, antidiabetic, antiobesity, etc. The aim of the present study was to investigate the possible anti-hyperlipidemic activity of Cucumis melo fruit peel (CMFP) methanolic and aqueous extract in high cholesterol diet induced hyperlipidemia in rats. Treatment with CMFP methanolic and aqueous extract showed significant (P<0.01) reduction in gain in body weight, serum lipid profile like total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) level, atherogenic index and increased the serum high density lipoprotein cholesterol (HDL-C) levels in 28 days treatment when compared to the hyperlipidemic control group. The fecal excretion of bile acids and sterols was further increased upon treatment with CMFP methanolic and aqueous extract and standard drug. Administration of methanolic extract of CMFP at a dose of 500 mg/kg showed higher antihyperlipidemic activity as compared to other extract treated groups. The results concluded that CMFP methanolic extract (500 mg/kg) have potent antihyperlipidemic activity in high cholesterol diet induced hyperlipidemia model and which is equipotent activity when compared with atorvastatin treated group.
    • Accession Number:
      0 (Biomarkers)
      0 (Cholesterol, Dietary)
      0 (Cholesterol, HDL)
      0 (Cholesterol, LDL)
      0 (Hypolipidemic Agents)
      0 (Plant Extracts)
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20121002 Date Completed: 20130122 Latest Revision: 20191210
    • Publication Date:
      20231215
    • Accession Number:
      10.1515/1553-3840.1580
    • Accession Number:
      23023565