Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.

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  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-232X (Electronic) Linking ISSN: 14345161 NLM ISO Abbreviation: J Hum Genet Subsets: MEDLINE
    • Publication Information:
      Publication: 2009- : London : Nature Pub. Group
      Original Publication: Tokyo : Springer-Verlag, c1998-
    • Subject Terms:
      Genetic Predisposition to Disease*; Asian People/*genetics ; Biomarkers/*analysis ; Diabetes Mellitus, Type 2/*genetics ; Polymorphism, Single Nucleotide/*genetics; Aged ; Blood Glucose/metabolism ; Case-Control Studies ; Delta-5 Fatty Acid Desaturase ; Diabetes Mellitus, Type 2/metabolism ; Female ; Genome-Wide Association Study ; Genotype ; Humans ; Insulin/metabolism ; Middle Aged ; Phenotype ; Risk Factors
    • Abstract:
      The aim of the present study was to explore the role of variations with modest effects (previously identified by a large-scale meta-analysis in European populations) in the genetic background of type 2 diabetes (T2D) and diabetes-related traits in a Japanese population. We enrolled 2632 Japanese subjects with T2D and 2050 non-diabetic subjects. We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively). Subjects with more risk alleles related to nine SNPs had an increased risk of T2D (P=0.0017), as well as a higher fasting plasma glucose level (P=0.018), higher HbA(1c) level (P=0.013) and lower HOMA-β (P=0.033) compared with subjects who had fewer risk alleles. We identified a significant association of a SNP of FADS1 and a SNP near PROX1 with T2D in a Japanese population. The present findings suggest that inclusion of SNPs with a tendency to increase the disease risk captured more of the genetic background of T2D than that revealed by only assessing significant SNPs.
    • Comments:
      Erratum in: J Hum Genet. 2012 Dec;57(12):809.
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Delta-5 Fatty Acid Desaturase)
      0 (Insulin)
      EC 1.14.19.3 (FADS1 protein, human)
    • Publication Date:
      Date Created: 20120921 Date Completed: 20131105 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      10.1038/jhg.2012.110
    • Accession Number:
      22992776