[Use of sugammadex in patients undergoing caesarean section using general anesthesia with rocuronium].

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  • Additional Information
    • Source:
      Publisher: Nippon Masui Gakki Country of Publication: Japan NLM ID: 0413707 Publication Model: Print Cited Medium: Print ISSN: 0021-4892 (Print) Linking ISSN: 00214892 NLM ISO Abbreviation: Masui Subsets: MEDLINE
    • Publication Information:
      Publication: Tokyo : Nippon Masui Gakki
      Original Publication: Tokyo.
    • Subject Terms:
      Androstanols*/antagonists & inhibitors ; Anesthesia, General* ; Anesthesia, Obstetrical* ; Cesarean Section* ; Neuromuscular Nondepolarizing Agents*/antagonists & inhibitors; gamma-Cyclodextrins/*administration & dosage; Adult ; Anesthesia Recovery Period ; Female ; Humans ; Pregnancy ; Rocuronium ; Sugammadex ; Thiopental ; Young Adult ; gamma-Cyclodextrins/pharmacology
    • Abstract:
      Recently, rocuronium is being used in patients for caesarean section undergoing general anesthesia instead of suxamethonium. An increased dose of rocuronium improves intubating conditions but prolongs neuromuscular blockade. Sugammadex reverses rapidly and predictably even profound rocuronium-induced neuromuscular blockade. We experienced 13 cases of caesarean section patients undergoing general anesthesia with thiopental (3.5 mg x kg(-1)) and rocuronium (0.9 mg x kg(-1)). At the end of surgery, sugammadex (2 mg x kg(-1)) was administered every 3 minutes repeatedly until TOF>0.9. In two patients, neuromuscular blockade spontaneously recovered to TOF>0.9 at the end of surgery. In most patients administered sugammadex, TOF recovered to more than 0.9 within a few minutes. However, in one patient who had chronic renal failure (creatinine clearance rate: 12 ml x min(-1)), 10 minutes were required for TOF to recover to more than 0.7, and TOF never reached 0.9. All patients were successfully intubated at the first attempt. No signs of recurarization or adverse effects related to sugammadex were noted in the perioperative period.
    • Accession Number:
      0 (Androstanols)
      0 (Neuromuscular Nondepolarizing Agents)
      0 (gamma-Cyclodextrins)
      361LPM2T56 (Sugammadex)
      JI8Z5M7NA3 (Thiopental)
      WRE554RFEZ (Rocuronium)
    • Publication Date:
      Date Created: 20120921 Date Completed: 20130103 Latest Revision: 20181201
    • Publication Date:
      20240513
    • Accession Number:
      22991799