Deregulation of MTDH gene expression in gastric cancer.

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  • Author(s): Baygi ME;Baygi ME; Nikpour P
  • Source:
    Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2012; Vol. 13 (6), pp. 2833-6.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Print Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention,
    • Subject Terms:
      Gene Expression Regulation, Neoplastic*; Cell Adhesion Molecules/*genetics ; Stomach Neoplasms/*genetics; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Adhesion Molecules/biosynthesis ; Gastric Mucosa/metabolism ; Humans ; Iran ; Membrane Proteins ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins ; Stomach Neoplasms/metabolism ; Transcription, Genetic
    • Abstract:
      Aim: Gastric cancer is the third most frequent cause of cancer mortality worldwide. In Iran, it is one of the leading causes at the national level. Localized at chromosome 8q22, the human MTDH gene has been reported to be over-expressed in a spectrum of malignancies. However, since there is a lack of data concerning with expression in gastric cancer at the transcriptional level, in this study we evaluated MTDH expression in Iranian cases.
      Methods: Totally, thirty paired gastric samples were examined by quantitative real-time RT-PCR.
      Results: Although the mRNA expression was significantly elevated in 46.6% of the examined tumor tissues; its expression was low in others (36.6%). Moreover, there was only a marginal statistical difference between the MTDH gene expression of all tumor specimens compared to their paired non-tumor ones and no statistically significant association with the grades and types of the tumors.
      Conclusion: Taken together, our results demonstrated that expression of MTDH at the transcriptional level may be increased in gastric cancer tissue samples but with considerable heterogeneity. Due to this, it may have the potential to be used as a target for diagnostic/therapeutic purposes only in a subset of patients.
    • Accession Number:
      0 (Biomarkers, Tumor)
      0 (Cell Adhesion Molecules)
      0 (MTDH protein, human)
      0 (Membrane Proteins)
      0 (RNA, Messenger)
      0 (RNA-Binding Proteins)
    • Publication Date:
      Date Created: 20120904 Date Completed: 20130227 Latest Revision: 20201209
    • Publication Date:
      20231215
    • Accession Number:
      10.7314/apjcp.2012.13.6.2833
    • Accession Number:
      22938468