Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs.

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  • Author(s): Surdyk KK;Surdyk KK; Sloan DL; Brown SA
  • Source:
    American journal of veterinary research [Am J Vet Res] 2012 Sep; Vol. 73 (9), pp. 1485-90.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 0375011 Publication Model: Print Cited Medium: Internet ISSN: 1943-5681 (Electronic) Linking ISSN: 00029645 NLM ISO Abbreviation: Am J Vet Res Subsets: MEDLINE
    • Publication Information:
      Publication: Schaumburg, Ill. : American Veterinary Medical Association
      Original Publication: Chicago : American Veterinary Medical Assn.
    • Subject Terms:
      Carbazoles/*pharmacology ; Cyclooxygenase 2 Inhibitors/*pharmacology ; Dogs/*physiology ; Etodolac/*pharmacology ; Hypovolemia/*veterinary ; Kidney/*drug effects; Animals ; Cross-Over Studies ; Diuretics/pharmacology ; Female ; Furosemide/pharmacology ; Glomerular Filtration Rate/drug effects ; Glomerular Filtration Rate/physiology ; Glomerular Filtration Rate/veterinary ; Hypovolemia/physiopathology ; Kidney/blood supply ; Kidney/physiology ; Random Allocation ; p-Aminohippuric Acid/urine
    • Abstract:
      Objective: To determine the effects of carprofen and etodolac on renal function in euvolemic dogs and dogs with extracellular fluid volume depletion induced via administration of furosemide.
      Animals: 12 female Beagles.
      Procedures: Dogs received a placebo, furosemide, carprofen, etodolac, furosemide and carprofen, and furosemide and etodolac. The order in which dogs received treatments was determined via a randomization procedure. Values of urine specific gravity, various plasma biochemical variables, glomerular filtration rate (GFR [urinary clearance of creatinine]), and renal plasma flow (urinary clearance of para-aminohippuric acid) were determined before and after 8 days of drug administration. A washout time of approximately 12 days was allowed between treatment periods.
      Results: Administration of furosemide, furosemide and carprofen, and furosemide and etodolac caused changes in urine specific gravity and values of plasma biochemical variables. Administration of carprofen or etodolac alone did not have a significant effect on renal plasma flow or GFR. Concurrent administration of furosemide and carprofen or furosemide and etodolac caused a significant decrease in GFR. After 12-day washout periods, mean values of GFR were similar to values before drug administration for all treatments.
      Conclusions and Clinical Relevance: Results indicated GFR decreased after 8 days of concurrent administration of furosemide and carprofen or furosemide and etodolac to dogs. Administration of preferential cyclooxygenase-2 inhibitors to dogs with extracellular fluid volume depletion or to dogs treated with diuretics may transiently impair renal function.
    • Accession Number:
      0 (Carbazoles)
      0 (Cyclooxygenase 2 Inhibitors)
      0 (Diuretics)
      2M36281008 (Etodolac)
      7LXU5N7ZO5 (Furosemide)
      FFL0D546HO (carprofen)
      Y79XT83BJ9 (p-Aminohippuric Acid)
    • Publication Date:
      Date Created: 20120829 Date Completed: 20130129 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10.2460/ajvr.73.9.1485
    • Accession Number:
      22924732