[Is there still a place for bone allografts in orthopedic surgery in 2011?].

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  • Author(s): Delloye C;Delloye C
  • Source:
    Bulletin et memoires de l'Academie royale de medecine de Belgique [Bull Mem Acad R Med Belg] 2011; Vol. 166 (7-9), pp. 317-26; discussion 327-8.
  • Publication Type:
    Lecture
  • Language:
    French
  • Additional Information
    • Transliterated Title:
      Y a-t-il encore une place en 2011 pour les allogreffes osseuses en chirurgie orthopédique?
    • Source:
      Publisher: Académie royale de médecine de Belgique Country of Publication: Belgium NLM ID: 7608462 Publication Model: Print Cited Medium: Print ISSN: 0377-8231 (Print) Linking ISSN: 03778231 NLM ISO Abbreviation: Bull Mem Acad R Med Belg Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bruxelles, Académie royale de médecine de Belgique.
    • Subject Terms:
      Bone Transplantation/*methods ; Orthopedics/*methods ; Transplantation, Homologous/*methods; Bone Neoplasms/surgery ; Bone Transplantation/trends ; Cell- and Tissue-Based Therapy/methods ; Fractures, Bone/surgery ; Humans ; Orthopedics/trends ; Plastic Surgery Procedures ; Transplantation, Homologous/trends
    • Abstract:
      The place of bone allograft in contemporary orthopaedic surgery is discussed. Bone allograft can be prepared from retrieved femoral heads for fracture or osteoarthritis and are used as a filling material. Demineralized bone matrix is a cortical bone that has been exposed to a demineralizing solution. Doing so, the growth factors of the bone are exposed and will be able to induce the formation of new bone cells from the host. This osteoinductive capacity makes the graft more active in the process of its incorporation and has been successfully used in the conservative treatment of aneurismal bone cysts. Massive bone allografts can be used as a full segment of a long bone to reconstruct part of the skeleton either alone with fixation or with a prosthetic device. Except demineralized bone, any other types of bone allograft serve as a biologic passive support for the migrating cells from the host. Cellular therapy is another approach that allows, considering the extensive use of in vitro expanded bone, forming cells originating either from the bone marrow or the fat tissue of the patient. However, this approach needs further clinical validation before being fully considered in patient.
    • Publication Date:
      Date Created: 20120816 Date Completed: 20120823 Latest Revision: 20221207
    • Publication Date:
      20240829
    • Accession Number:
      22891447