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Association of weight status with mortality in adults with incident diabetes.
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- Author(s): Carnethon MR;Carnethon MR; De Chavez PJ; Biggs ML; Lewis CE; Pankow JS; Bertoni AG; Golden SH; Liu K; Mukamal KJ; Campbell-Jenkins B; Dyer AR
- Source:
JAMA [JAMA] 2012 Aug 08; Vol. 308 (6), pp. 581-90.- Publication Type:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
- Publication Information: Original Publication: Chicago : American Medical Association, 1960-
- Subject Terms:
- Abstract: Context: Type 2 diabetes in normal-weight adults (body mass index [BMI] <25) is a representation of the metabolically obese normal-weight phenotype with unknown mortality consequences.
Objective: To test the association of weight status with mortality in adults with new-onset diabetes in order to minimize the influence of diabetes duration and voluntary weight loss on mortality.
Design, Setting, and Participants: Pooled analysis of 5 longitudinal cohort studies: Atherosclerosis Risk in Communities study, 1990-2006; Cardiovascular Health Study, 1992-2008; Coronary Artery Risk Development in Young Adults, 1987-2011; Framingham Offspring Study, 1979-2007; and Multi-Ethnic Study of Atherosclerosis, 2002-2011. A total of 2625 participants with incident diabetes contributed 27,125 person-years of follow-up. Included were men and women (age >40 years) who developed incident diabetes based on fasting glucose 126 mg/dL or greater or newly initiated diabetes medication and who had concurrent measurements of BMI. Participants were classified as normal weight if their BMI was 18.5 to 24.99 or overweight/obese if BMI was 25 or greater.
Main Outcome Measures: Total, cardiovascular, and noncardiovascular mortality.
Results: The proportion of adults who were normal weight at the time of incident diabetes ranged from 9% to 21% (overall 12%). During follow-up, 449 participants died: 178 from cardiovascular causes and 253 from noncardiovascular causes (18 were not classified). The rates of total, cardiovascular, and noncardiovascular mortality were higher in normal-weight participants (284.8, 99.8, and 198.1 per 10,000 person-years, respectively) than in overweight/obese participants (152.1, 67.8, and 87.9 per 10,000 person-years, respectively). After adjustment for demographic characteristics and blood pressure, lipid levels, waist circumference, and smoking status, hazard ratios comparing normal-weight participants with overweight/obese participants for total, cardiovascular, and noncardiovascular mortality were 2.08 (95% CI, 1.52-2.85), 1.52 (95% CI, 0.89-2.58), and 2.32 (95% CI, 1.55-3.48), respectively.
Conclusion: Adults who were normal weight at the time of incident diabetes had higher mortality than adults who are overweight or obese. - Comments: Erratum in: JAMA. 2012 Nov 28;308(20):2085.
Comment in: JAMA. 2012 Aug 8;308(6):619-20. (PMID: 22871873)
Comment in: Nat Rev Endocrinol. 2012 Oct;8(10):567. (PMID: 22926099)
Comment in: Dtsch Med Wochenschr. 2012 Oct;137(42):2140. (PMID: 23055352)
Comment in: JAMA. 2012 Nov 28;308(20):2079; author reply 2080-1. (PMID: 23188014)
Comment in: JAMA. 2012 Nov 28;308(20):2079-80; author reply 2080-1. (PMID: 23188015)
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Am J Clin Nutr. 1981 Aug;34(8):1617-21. (PMID: 7270486) - Grant Information: N01HC55020 United States HL NHLBI NIH HHS; N01-HC-95162 United States HC NHLBI NIH HHS; N01HC55018 United States HL NHLBI NIH HHS; N01-HC-85085 United States HC NHLBI NIH HHS; R56 AG020098 United States AG NIA NIH HHS; P30 DK079637 United States DK NIDDK NIH HHS; N01-HC-95159 United States HC NHLBI NIH HHS; N01-HC-85082 United States HC NHLBI NIH HHS; N01HC95095 United States HL NHLBI NIH HHS; N01HC48047 United States HL NHLBI NIH HHS; HL080295 United States HL NHLBI NIH HHS; N01HC48048 United States HL NHLBI NIH HHS; R01 HL078972 United States HL NHLBI NIH HHS; R01 AG015928 United States AG NIA NIH HHS; U01 HL080295 United States HL NHLBI NIH HHS; N01-HC-48047 United States HC NHLBI NIH HHS; N01HC48049 United States HL NHLBI NIH HHS; N01-HC-55022 United States HC NHLBI NIH HHS; N01-HC-85081 United States HC NHLBI NIH HHS; N01-HC-95163 United States HC NHLBI NIH HHS; N01 HC015103 United States HC NHLBI NIH HHS; N01-HC-55016 United States HC NHLBI NIH HHS; N01HC95169 United States HL NHLBI NIH HHS; AG-20098 United States AG NIA NIH HHS; N01-HC-95095 United States HC NHLBI NIH HHS; N01HC55022 United States HL NHLBI NIH HHS; N01-HC-95165 United States HC NHLBI NIH HHS; N01HC55222 United States HL NHLBI NIH HHS; N01-HC-55021 United States HC NHLBI NIH HHS; N01-HC-85086 United States HC NHLBI NIH HHS; N01HC55015 United States HL NHLBI NIH HHS; N01HC85086 United States HL NHLBI NIH HHS; N01-HC-48050 United States HC NHLBI NIH HHS; AG-027058 United States AG NIA NIH HHS; N01-HC-55019 United States HC NHLBI NIH HHS; N01 HC-55222 United States HC NHLBI NIH HHS; R21 DK082903 United States DK NIDDK NIH HHS; N01-HC-55015 United States HC NHLBI NIH HHS; N01-HC-95169 United States HC NHLBI NIH HHS; N01-HC-95164 United States HC NHLBI NIH HHS; N01HC95165 United States HL NHLBI NIH HHS; N01HC95159 United States HL NHLBI NIH HHS; N01-HC-48049 United States HC NHLBI NIH HHS; N01-HC-85083 United States HC NHLBI NIH HHS; N01-HC-75150 United States HC NHLBI NIH HHS; N01-HC-55020 United States HC NHLBI NIH HHS; N01-HC-85080 United States HC NHLBI NIH HHS; N01-HC-95160 United States HC NHLBI NIH HHS; N01HC55016 United States HL NHLBI NIH HHS; R01 HL080295 United States HL NHLBI NIH HHS; 5 R01 HL078972 United States HL NHLBI NIH HHS; R01 AG020098 United States AG NIA NIH HHS; N01HC48050 United States HL NHLBI NIH HHS; N01HC55019 United States HL NHLBI NIH HHS; N01HC75150 United States HL NHLBI NIH HHS; N01-HC-85079 United States HC NHLBI NIH HHS; N01-HC-95161 United States HC NHLBI NIH HHS; N01-HC-85239 United States HC NHLBI NIH HHS; N01-HC-48048 United States HC NHLBI NIH HHS; AG-023629 United States AG NIA NIH HHS; N01HC85079 United States HL NHLBI NIH HHS; N01-HC-55018 United States HC NHLBI NIH HHS; N01HC55021 United States HL NHLBI NIH HHS; R01 AG023629 United States AG NIA NIH HHS; R01 AG027058 United States AG NIA NIH HHS; N01 HC045133 United States HC NHLBI NIH HHS; N01 HC035129 United States HC NHLBI NIH HHS; R56 AG023629 United States AG NIA NIH HHS; R21DK082903 United States DK NIDDK NIH HHS; N01-HC-85084 United States HC NHLBI NIH HHS
- Publication Date: Date Created: 20120809 Date Completed: 20120809 Latest Revision: 20220408
- Publication Date: 20240628
- Accession Number: PMC3467944
- Accession Number: 10.1001/jama.2012.9282
- Accession Number: 22871870
- Source:
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