[Thyroid associated orbitopathy].

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  • Author(s): Alves M;Alves M; Neves C; Carvalho D; Medina JL
  • Source:
    Acta medica portuguesa [Acta Med Port] 2011 Nov-Dec; Vol. 24 (6), pp. 1041-50. Date of Electronic Publication: 2012 Feb 20.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Portuguese
  • Additional Information
    • Transliterated Title:
      Abordagem da orbitopatia associada à tiróide.
    • Source:
      Publisher: Centro Editor Livreiro da Ordem dos Médicos Country of Publication: Portugal NLM ID: 7906803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1646-0758 (Electronic) Linking ISSN: 0870399X NLM ISO Abbreviation: Acta Med Port Subsets: MEDLINE
    • Publication Information:
      Publication: Lisboa : Centro Editor Livreiro da Ordem dos Médicos
      Original Publication: Lisboa [s.n.]
    • Subject Terms:
      Orbital Diseases/*etiology ; Thyroid Diseases/*complications; Decision Trees ; Humans ; Orbital Diseases/diagnosis ; Orbital Diseases/therapy ; Patient Selection ; Severity of Illness Index
    • Abstract:
      Thyroid associated orbitopathy is a clinical entity with pathogenic mechanisms not fully understood, and appears in about 90% of cases in association with hyperthyroidism of Graves' disease. Its approach involves the recognition of typical features and the exclusion of other diseases in the less common presentations. The treatment is conditioned by the determination of the activity and severity of the disease. The restoration of the euthyroid state and avoiding of hypothyroidism are essential in mitigating the progression of orbitopathy. Glucocorticoid intravenous therapy is the treatment of choice in the active phase and surgical treatment in the inactive phase. Radiotherapy and cyclosporine in combination with corticosteroids are alternatives when monotherapy is insufficient in the active phase. Treatment should be instituted in specialized centers, with ophthalmologists and endocrinologists acting in synergy to avoid consequences of delays in intervention and in optimizing therapy.
    • Publication Date:
      Date Created: 20120621 Date Completed: 20121126 Latest Revision: 20120620
    • Publication Date:
      20231215
    • Accession Number:
      22713200