[Simvastatin influence on carotid atherosclerotic disease regression].

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  • Author(s): Vasić D; Radmili O; Davidović L; Vraneš M
  • Source:
    Srpski arhiv za celokupno lekarstvo [Srp Arh Celok Lek] 2012 Mar-Apr; Vol. 140 (3-4), pp. 164-7.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Serbian
  • Additional Information
    • Source:
      Publisher: Srpski Lekarski Drustvo Country of Publication: Serbia NLM ID: 0027440 Publication Model: Print Cited Medium: Print ISSN: 0370-8179 (Print) Linking ISSN: 03708179 NLM ISO Abbreviation: Srp Arh Celok Lek Subsets: MEDLINE
    • Publication Information:
      Publication: Beograd : Srpski Lekarski Drustvo
      Original Publication: Belgrade.
    • Subject Terms:
      Carotid Artery Diseases/*drug therapy ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use ; Simvastatin/*therapeutic use; Adult ; Aged ; Carotid Artery Diseases/diagnosis ; Carotid Intima-Media Thickness ; Female ; Humans ; Male ; Middle Aged
    • Abstract:
      Introduction: The measurement of intima-media thickness (IMT) of carotid arteries has emerged as the method of choice for determining the anatomic extent of atherosclerosis and assessing cardiovascular progression. Statins are used in the primary and secondary prevention of cardiovascular and cerebrovascular disorders so as to reduce morbidity and mortality.
      Objective: To evaluate the effects of treatment with simvastatin in patients with elevated cholesterol levels and increased values of carotid arteries IMT.
      Methods: The study of 275 patients (155 male and 115 female, aged 37-79 years, mean 60.86 years) was performed from January 2008 - January 2010 at the Vascular and Endovascular Surgery Clinic of the Clinical Centre of Serbia. All patients were treated with simvastatin administered once a day for 6 months.
      Results: Simvastatin treatment resulted in a statistically signuficant decrease of the IMT thickness of the right common carotid artery. There was no statistically significant reduction in the IMT of the left common carotid artery as well as in the IMT of the right and left internal carotid arteries.
      Conclusion: Long-term simvastatin treatment results in the regression or slowing down atherosclerosis in symptomatic, as well as in asymptomatic patients with a lower grade of carotid stenosis (IMT below 2.5 mm).
    • Accession Number:
      0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
      AGG2FN16EV (Simvastatin)
    • Publication Date:
      Date Created: 20120602 Date Completed: 20120625 Latest Revision: 20190918
    • Publication Date:
      20240829
    • Accession Number:
      10.2298/sarh1204164v
    • Accession Number:
      22650101