[Second breast-conserving surgery and reirradiation with interstitial high-dose-rate brachytherapy for the management of intra-breast recurrences -- 5-year results].

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  • Additional Information
    • Transliterated Title:
      Második emlõmegtartó mûtét és ismételt besugárzás szövetközi nagy dózisteljesítményû brachyterápiával az emlõrák lokális kiújulásának kezelésére - 5 éves eredmények.
    • Source:
      Publisher: Professional Publishing Hungary Kft Country of Publication: Hungary NLM ID: 9313833 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0025-0244 (Print) Linking ISSN: 00250244 NLM ISO Abbreviation: Magy Onkol Subsets: MEDLINE
    • Publication Information:
      Publication: Budapest : Professional Publishing Hungary Kft.
      Original Publication: Budapest : Medicina, [1957-
    • Subject Terms:
      Brachytherapy*/methods ; Mastectomy, Segmental*; Breast Neoplasms/*radiotherapy ; Breast Neoplasms/*surgery ; Neoplasm Recurrence, Local/*radiotherapy ; Neoplasm Recurrence, Local/*surgery; Adult ; Aged ; Carcinoma, Ductal, Breast/radiotherapy ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Lobular/radiotherapy ; Carcinoma, Lobular/surgery ; Dose Fractionation, Radiation ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm, Residual/diagnosis ; Patient Satisfaction ; Photons/therapeutic use ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/adverse effects ; Reoperation ; Retrospective Studies ; Treatment Outcome
    • Abstract:
      The purpose of our work was to evaluate the efficacy of second breast-conserving surgery (BCS) and reirradiation with interstitial high-dose-rate (HDR) brachytherapy (BT) for the management of local recurrences. Between 1999 and 2010, fifteen patients initially treated for breast carcinoma by BCS and radiation therapy who had isolated intra-breast recurrence underwent second BCS and perioperative HDR multicatheter BT. Breast cancer related events, late side effects, and cosmetic results were assessed. At a median follow-up of 62 months (range: 11-127) second local recurrence has not occurred, yielding a 100% mastectomy-free survival. Four patients (27%) developed subsequent distant metastasis and died of breast cancer. The 5-year actuarial rate of disease-free and overall survival was 69% and 85%, respectively. Cosmetic results were rated excellent, good, fair, poor, and unknown in 1 (7%), 10 (66%), 2 (13%), 1 (7%), and 1 (7%) patients, respectively. Grade 2 fibrosis and skin toxicity occurred in 1 (7%) and 1 (7%) patients. Asymptomatic fat necrosis was detected in 9 (60%) women. No patient developed grade 3-4 late side effects. Second BCS followed by partial breast reirradiation is a safe and effective option for the management of selected patients developing intra-breast recurrence after previous breast-conserving therapy. Perioperative HDR BT may decrease the risk of second local relapse with acceptable cosmetic results and low rate of late side effects.
    • Publication Date:
      Date Created: 20120526 Date Completed: 20120712 Latest Revision: 20220410
    • Publication Date:
      20240829
    • Accession Number:
      MagyOnkol.2012.56.2.68
    • Accession Number:
      22629542