Delivery of drugs to the brain via the blood brain barrier using colloidal carriers.

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  • Author(s): Tucker IG;Tucker IG; Yang L; Mujoo H
  • Source:
    Journal of microencapsulation [J Microencapsul] 2012; Vol. 29 (5), pp. 475-86. Date of Electronic Publication: 2012 May 07.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8500513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5246 (Electronic) Linking ISSN: 02652048 NLM ISO Abbreviation: J Microencapsul Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London [England] ; Philadelphia : Taylor & Francis, c1984-
    • Subject Terms:
      Blood-Brain Barrier/*metabolism ; Colloids/*analysis ; Drug Delivery Systems/*methods ; Nanoparticles/*analysis ; Pharmaceutical Preparations/*administration & dosage; Animals ; Brain/blood supply ; Colloids/metabolism ; Humans
    • Abstract:
      Delivering drugs to the brain is challenging given the selective permeability of the blood brain barrier (BBB). Targeted colloidal carriers containing drug payloads offer some promise for enhanced and perhaps selective delivery to brain. This review examines the recent literature and identifies issues to be addressed if these systems are to be rationally designed. These include opsonization of nanoparticles and off-target clearance; the cerebral microvasculature, flow of nanoparticles in capillaries and binding to the capillary wall; and transcytosis. Capillary architecture, blood flow and BBB permeability are affected by disease and age and there are species differences. These complexities caution against making extravagant claims for a particular nanosystem but they also highlight the rich opportunities and need for critical research in this field.
    • Accession Number:
      0 (Colloids)
      0 (Pharmaceutical Preparations)
    • Publication Date:
      Date Created: 20120509 Date Completed: 20121113 Latest Revision: 20120712
    • Publication Date:
      20240829
    • Accession Number:
      10.3109/02652048.2012.658445
    • Accession Number:
      22563886