Extracorporeal bypass model of blood circulation for the study of microvascular hemodynamics.

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  • Author(s): Nam KH;Nam KH; Yeom E; Lee SJ
  • Source:
    Microvascular research [Microvasc Res] 2012 May; Vol. 83 (3), pp. 372-5. Date of Electronic Publication: 2012 Feb 23.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0165035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9319 (Electronic) Linking ISSN: 00262862 NLM ISO Abbreviation: Microvasc Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Hemodynamics* ; Microcirculation*; Femoral Artery/*pathology ; Jugular Veins/*pathology; Animals ; Blood Flow Velocity ; Equipment Design ; Male ; Microscopy/methods ; Polytetrafluoroethylene/analogs & derivatives ; Polytetrafluoroethylene/chemistry ; Pulsatile Flow ; Rats ; Rats, Sprague-Dawley ; Refractometry ; Rheology
    • Abstract:
      Many studies have been performed to better understand the hemodynamics in microvessels, such as arterioles and venules. However, due to the heterogeneous features of size, shape, blood-flow velocity, and pulsatility of microvessels, conducting a systematic study on these factors has been almost impossible. Although in vitro studies have been performed for this purpose, the usefulness of in vitro data is limited by the fact that the rheological properties of blood are changed as blood is exposed to in vitro environments. The purpose of the present study is to investigate the feasibility of a rat extracorporeal bypass model that combines in vivo and in vitro models. An arteriovenous shunt loop with a sub-bypass loop of fluorinated ethylene propylene (FEP) microtube was constructed between the jugular vein and femoral artery of a rat. Three pinch valves were installed in the main loop. Microscopic images of the blood flow in the FEP tube were sequentially captured with a high-speed camera, and the whole velocity field information was obtained using a micro-particle image velocimetry technique. Experimental results reveal that the velocity fields of the blood flow inside the microtube are well measured because the FEP tube is transparent and has nearly the same refractive index as water. The flow velocity and the pulsatility index of the blood flow in the microtube can be controlled by adjusting the three pinch valves installed upstream, midstream, and downstream of the bypass loop. This hybrid model that combines in vivo and in vitro models can be useful in studying microvascular hemodynamics.
      (Copyright © 2012 Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (fluorinated ethylene propylene)
      9002-84-0 (Polytetrafluoroethylene)
    • Publication Date:
      Date Created: 20120306 Date Completed: 20120809 Latest Revision: 20120410
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.mvr.2012.02.007
    • Accession Number:
      22386655