Gallbladder sludge on ultrasound is predictive of increased liver enzymes and total bilirubin in cats.

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  • Author(s): Harran N;Harran N; d'Anjou MA; Dunn M; Beauchamp G
  • Source:
    The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2011 Sep; Vol. 52 (9), pp. 999-1003.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Canadian Veterinary Medical Association Country of Publication: Canada NLM ID: 0004653 Publication Model: Print Cited Medium: Internet ISSN: 0008-5286 (Print) Linking ISSN: 00085286 NLM ISO Abbreviation: Can Vet J Subsets: MEDLINE
    • Publication Information:
      Publication: Ottawa : Canadian Veterinary Medical Association
      Original Publication: Guelph, Ont., Canadian Veterinary Medical Assn.
    • Subject Terms:
      Biliary Tract Diseases/*veterinary ; Bilirubin/*blood ; Cat Diseases/*diagnosis ; Gallbladder/*diagnostic imaging ; Liver/*enzymology ; Liver Diseases/*veterinary; Alkaline Phosphatase/blood ; Animals ; Aspartate Aminotransferases/blood ; Biliary Tract Diseases/blood ; Biliary Tract Diseases/diagnosis ; Biliary Tract Diseases/diagnostic imaging ; Cat Diseases/blood ; Cat Diseases/diagnostic imaging ; Cats ; Female ; Liver Diseases/blood ; Liver Diseases/diagnosis ; Liver Diseases/diagnostic imaging ; Male ; Predictive Value of Tests ; Prevalence ; Retrospective Studies ; Ultrasonography
    • Abstract:
      The purposes of this retrospective study were to assess the prevalence of gallbladder sludge (GBS) in a population of cats presented for abdominal ultrasound in a teaching hospital and to determine its association with increased serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (TB). Gallbladder sludge was detected in 152 (14%) of the cats undergoing abdominal ultrasound between 2004 and 2008. This population was compared to a control group of 32 cats without GBS. Alanine aminotransferase, ALP, and TB mean values were significantly higher in cats with GBS than in controls (P ≤ 0.0005) and odds for increased values in cats with GBS were 4.2 [95% confidence interval (CI): 1.6 to 11.0], 9.5 (95% CI: 2.2 to 41.7), and 4.1 (95% CI: 1.5 to 11.5), respectively (P ≤ 0.007). In conclusion, GBS is an uncommon ultrasonographic finding in cats that is predictive of increased liver enzymes and TB. More studies are needed to establish potential links between GBS and hepatobiliary disease in cats.
    • References:
      Best Pract Res Clin Gastroenterol. 2006;20(6):1053-62. (PMID: 17127187)
      Ann Intern Med. 1999 Feb 16;130(4 Pt 1):301-11. (PMID: 10068389)
      Vet Clin North Am Small Anim Pract. 2009 May;39(3):439-67. (PMID: 19524788)
      Curr Gastroenterol Rep. 2001 Apr;3(2):166-73. (PMID: 11276386)
      J Clin Ultrasound. 1980 Jun;8(3):193-200. (PMID: 6769957)
      Am J Epidemiol. 1987 Nov;126(5):912-21. (PMID: 3310613)
      Vet Clin North Am Small Anim Pract. 2007 Mar;37(2):297-333, vii. (PMID: 17336677)
      Vet Radiol Ultrasound. 1998 May-Jun;39(3):206-10. (PMID: 9634188)
      Dig Liver Dis. 2003 Jul;35 Suppl 3:S39-45. (PMID: 12974509)
      Vet Clin North Am Small Anim Pract. 2009 May;39(3):543-98. (PMID: 19524793)
      Surg Endosc. 1987;1(1):41-9. (PMID: 3332730)
      Vet Clin North Am Small Anim Pract. 1984 Nov;14(6):1201-30. (PMID: 6393553)
      Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):439-47. (PMID: 17899979)
      Vet Radiol Ultrasound. 2001 Mar-Apr;42(2):149-55. (PMID: 11327363)
      J Hepatol. 2000 Sep;33(3):352-60. (PMID: 11019989)
      J Clin Gastroenterol. 1990 Dec;12(6):656-62. (PMID: 2266242)
      Hepatology. 1994 Aug;20(2):291-4. (PMID: 8045489)
      Scand J Gastroenterol. 1996 Mar;31(3):273-8. (PMID: 8833358)
      Vet Clin North Am Small Anim Pract. 1995 Mar;25(2):375-85. (PMID: 7785169)
      Gastroenterology. 1986 Mar;90(3):677-86. (PMID: 3943697)
      J Small Anim Pract. 2002 Jun;43(6):247-53. (PMID: 12074289)
      Semin Vet Med Surg Small Anim. 1997 Feb;12(1):10-21. (PMID: 9057485)
    • Accession Number:
      EC 2.6.1.1 (Aspartate Aminotransferases)
      EC 3.1.3.1 (Alkaline Phosphatase)
      RFM9X3LJ49 (Bilirubin)
    • Publication Date:
      Date Created: 20120302 Date Completed: 20120406 Latest Revision: 20211021
    • Publication Date:
      20231215
    • Accession Number:
      PMC3157076
    • Accession Number:
      22379201